Reduced kidney function is associated with poorer domain‐specific cognitive performance in community‐dwelling older adults

Autor: Adam H. Dyer, Eamon Laird, Leane Hoey, Catherine F. Hughes, Helene McNulty, Mary Ward, J. J. Strain, Maurice O’Kane, Fergal Tracey, Anne M. Molloy, Conal Cunningham, Donal J. Sexton, Kevin McCarroll
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Geriatric Psychiatry. 37
ISSN: 1099-1166
0885-6230
Popis: Whilst chronic kidney disease has been associated with cognitive impairment, the association between reduced estimated Glomerular Filtration Rate (eGFR) and domain-specific cognitive performance is less clear and may represent an important target for the promotion of optimal brain health in older adults.Participants aged60 years from the Trinity-Ulster-Department of Agriculture study underwent detailed cognitive assessment using the Mini-Mental State Examination (Mini-Mental State Examination (MMSE)), Frontal Assessment Battery (FAB) and Repeatable Battery for Assessment of Neuropsychological Status (RBANS). Poisson and linear regression models assessed the relationship between eGFR strata and cognitive performance.In 4887 older adults (73.9 ± 8.3 years; 67.7% female), declining eGFR strata was associated with greater likelihood of error on the MMSE/FAB and poorer overall performance on the RBANS. Following robust covariate adjustment, findings were greatest for GFR45 ml/ml/1.73 mReduced kidney function was associated with poorer global and domain-specific neuropsychological performance. Associations were strongest with eGFR45 ml/min/1.73 m
Databáze: OpenAIRE
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