Autonomic modulation in patients with congenital generalized lipodystrophy (Berardinelli-Seip syndrome)
| Autor: | Antonio Guedes do Rêgo, Ruy S. Moraes, José Brandão-Neto, Carlos Alberto de Faria, Dário C. Sobral-Filho, Eryvaldo Sócrates Tabosa do Egito, Maria de Fátima Paiva Baracho |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Diastole Hemodynamics Blood Pressure Autonomic Nervous System Left ventricular hypertrophy Congenital generalized lipodystrophy Electrocardiography Young Adult Insulin resistance Lipodystrophy Congenital Generalized Heart Rate Physiology (medical) Internal medicine Humans Medicine Systole business.industry medicine.disease Adaptation Physiological Endocrinology Blood pressure Homeostatic model assessment Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | EP Europace. 11:763-769 |
| ISSN: | 1532-2092 1099-5129 |
| Popis: | Aims This study was designed to assess cardiac autonomic regulation in congenital generalized lipodystrophy (CGL) patients using 24 h heart rate variability (HRV). Methods and results A cross-sectional study was carried out to evaluate 18 patients with CGL and 19 healthy controls matched by sex and age. We measured blood pressure, plasma concentrations of glucose, triglycerides, cholesterol, high-density lipoprotein-cholesterol, insulin resistance by the homeostatic model assessment (HOMA-R), left ventricular mass (LVM) (by two-dimensional echocardiography), and 24 h HRV (by the time domain indices MeanRR, SDNN, and rMSSD). Compared with controls, CGL patients had higher blood pressure (systolic, 131.1 vs. 106.3 mmHg, P < 0.05; diastolic, 85.0 vs. 68.2 mmHg, P < 0.05) and 10 patients met criteria for arterial hypertension and concentric left ventricular hypertrophy (LVM index ≥115 g/m2and relative left ventricular wall thickness ≥0.42). Patients with CGL had higher levels of glucose, triglycerides, cholesterol, and HOMA-R and 12 met criteria for type 2 diabetes mellitus. Compared with controls, CGL patients had lower MeanRR (639.8 vs. 780.5 ms, P < 0.001), SDNN (79.2 vs. 168.5 ms, P < 0.001), and rMSSD (15.8 vs. 59.6 ms, P < 0.001). In CGL patients, the reduction in HRV was independent of the metabolic and haemodynamic disturbances. Conclusion Congenital generalized lipodystrophy patients have abnormal autonomic modulation, reflected by increased heart rate and pronounced reduction in HRV, independent of the metabolic and haemodynamic disturbances observed in this disorder. |
| Databáze: | OpenAIRE |
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