Brain Functional Connectivity Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children
| Autor: | Maria Suñol, Jordi Sunyer, Jesús Pujol, Gerard Martínez-Vilavella, Ignacio Martínez-Zalacaín, O. Contreras-Rodríguez, José M. Menchón, Carles Soriano-Mas, Dídac Macià, Cristina Saiz-Masvidal |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Obsessive-Compulsive Disorder medicine.medical_specialty Audiology Age and sex Article Neural Pathways Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Child Subclinical infection Brain Mapping medicine.diagnostic_test business.industry Functional connectivity Putamen 05 social sciences Confounding Brain Magnetic Resonance Imaging Obsessive compulsive symptoms Psychiatry and Mental health nervous system Female Functional magnetic resonance imaging Large group business 050104 developmental & child psychology |
| Zdroj: | J Am Acad Child Adolesc Psychiatry |
| ISSN: | 0890-8567 |
| Popis: | Objective Commonly observed subclinical obsessive-compulsive symptoms in healthy children may predispose to obsessive-compulsive disorder (OCD). Therefore, investigating the underlying neurobiology may be relevant to identify alterations in specific brain circuits potentially accounting for clinical heterogeneity in OCD without the confounding effects of clinical samples. We analyzed the brain correlates of different obsessive-compulsive symptoms in a large group of healthy children using functional connectivity measures. Method We evaluated 227 healthy children (52% girls; mean [SD] age 9.71 [0.86] years; range, 8–12.1 years). Participants underwent clinical assessment with the Obsessive-Compulsive Inventory–Child Version and a resting-state functional magnetic resonance imaging examination. Total and symptom-specific severity were correlated with voxelwise global functional connectivity degree values. Significant clusters were then used as seeds of interest in seed-to-voxel analyses. Modulating effects of age and sex were also assessed. Results Global functional connectivity of the left ventral putamen and medial dorsal thalamus correlated negatively with total obsessive-compulsive symptom severity. Seed-to-voxel analyses revealed specific negative correlations from these clusters with limbic, sensorimotor, and insular regions in association with obsessing, ordering, and doubt-checking symptoms, respectively. Hoarding symptoms were associated with negative correlations between the left medial dorsal thalamus and a widespread pattern of regions, with such associations modulated by sex and age. Conclusion Our findings concur with prevailing neurobiological models of OCD on the importance of cortico-striato-thalamo-cortical dysfunction to account for symptom severity. Notably, we showed that changes in cortico-striato-thalamo-cortical connectivity are present at subclinical stages, which may result in an increased vulnerability for OCD. Moreover, we mapped different symptom dimensions onto specific cortico-striato-thalamo-cortical circuit attributes. |
| Databáze: | OpenAIRE |
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