Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin
| Autor: | Kathryn Pennel, David W. Hill, Adam S. Venable, Brian K. McFarlin, Jill N. Best Sampson, Jakob L. Vingren, Andrea L. Henning |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Activities of daily living Physiology Inflammation Muscle damage Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Delayed onset muscle soreness medicine Leg press Multiplex business.industry Regular Article 030229 sport sciences Bioavailability 030104 developmental biology chemistry Physical therapy Curcumin Cytokines Molecular Medicine medicine.symptom business |
| Zdroj: | BBA Clinical |
| ISSN: | 2214-6474 |
| Popis: | Background Exercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be even more pronounced and present even in the absence of structured exercise. Methods The purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise). Subjects (N = 28) were randomly assigned to either curcumin (400 mg/day) or placebo (rice flour) and supplemented 2 days before to 4 days after EMID. Blood samples were collected prior to (PRE), and 1, 2, 3, and 4 days after EIMD to measure CK and inflammatory cytokines. Data were analyzed by ANOVA with P Highlights • Oral optimized curcumin supplementation reduced biological indices of muscle inflammation following exercise-induced muscle damage. • Oral optimized curcumin supplementation did not significantly reduced subjective quadriceps muscle soreness for this sample size following exercise induced muscle damage. • These findings support the use of oral, optimized curcumin supplementation to reduce the biological symptoms associated with exercise induced muscle damage. • The next logical step is to evaluated oral, optimized curcumin supplementation in an inflammatory clinical disease model. |
| Databáze: | OpenAIRE |
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