Increased ‘T Lymphocyte’ Bearing Fc Receptors for IgG in Pregnancy

Autor:	Zarina Goel, Michael H. Grieco, Khing S. Ong
Rok vydání:	1983
Předmět:	Adult Pregnancy biology Chemistry T-Lymphocytes T cell Immunology General Medicine T lymphocyte E rosettes medicine.disease medicine.anatomical_structure biology.protein medicine Humans Immunology and Allergy Female Lymphocytes Lymphocyte Culture Test Mixed Receptors Immunologic Antibody Receptor
Zdroj:	International Archives of Allergy and Immunology. 70:220-224
ISSN:	1423-0097 1018-2438
Popis:	T cell subpopulations as defined by E rosette formation and Fc receptors for immunoglobulins were determined, using ox red blood cells coated with the IgG or IgM fraction of rabbit anti-ox red blood cells antibody to form rosettes with the peripheral blood lymphocytes of 18 pregnant females and 12 healthy non-pregnant females. It was shown that the TG cell population in the pregnant females is significantly increased as compared to those in the nonpregnant controls (mean ± SEM %TG cells: 18 ± 1.2 vs. 9.6 ± 0.7; p < 0.001). By using peripheral blood from normal nonpregnant subjects it was also shown that To cells suppressed one-way mixed lymphocyte reactions (mean ± SEM suppression: 23 ± 7.2; p < 0.01). These findings suggest that the TG cell population may exert a suppressor function on the immune response to alloantigens and act in concert with other humoral factors to protect the fetus from rejection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e798451bc88ac73662b20b822ba06207 https://doi.org/10.1159/000233327 Zobrazit plný text záznamu