Disturbed Endocrine Function in the Psychoses
| Autor: | J. Bennie, Lawrence J. Whalley, J E Christie, Douglas Blackwood, H. Dick, George Fink, I. M. Blackburn |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Bipolar Disorder Hydrocortisone Thyrotropin Neurophysins Serotonergic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Endocrine system Disease process 030212 general & internal medicine Psychiatric Status Rating Scales Depressive Disorder Middle Aged Hormones Prolactin 030227 psychiatry Psychiatry and Mental health Endocrinology Psychotic Disorders Schizophrenia Female medicine.symptom Psychology Mania hormones hormone substitutes and hormone antagonists Homeostasis Hormone |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | Plasma concentrations of prolactin, growth hormone, cortisol, TSH, and the neurophysins were measured over 17 hours in 98 newly admitted psychiatric patients and 35 control subjects. Seventy patients had been free of psychotropic medication for three months. Patients with schizoaffective mania (SAM) differed significantly from control subjects by increased plasma Cortisol concentrations and decreased night-time TSH concentrations. The latter were also significantly lower than in both schizophrenic and manic disorder patients. Plasma Cortisol was increased to a lesser extent in other psychotic subgroups, and increases in prolactin were most marked in the affective psychoses. There was little diagnostic specificity for psychoses other than SAM. Higher Cortisol and prolactin levels may be due to the stimulatory effect of serotonergic pathways, but the neural mechanisms underlying lower night-time TSH levels in SAM are not known. The findings are not consistent with the view (a) that the hormonal changes of the psychoses simply reflect a non-specific response to stress, or (b) that the biological abnormalities of the psychoses can be accounted for by a single continuum of disturbance. |
| Databáze: | OpenAIRE |
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