Disk-shedding in the rat retina: lithium dampens the circadian rhythm but potentiates the light response
| Autor: | Ch. Remé, A. Wirz-Justice, U. Braschler, Kurt Munz |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Lithium (medication) Rat retina Lithium Biology Retina chemistry.chemical_compound Rhythm Internal medicine medicine Animals Photoreceptor Cells Circadian rhythm Molecular Biology Light response General Neuroscience Diurnal temperature variation Retinal Circadian Rhythm Rats Endocrinology chemistry Light effects on circadian rhythm sense organs Neurology (clinical) Photic Stimulation Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 523:167-170 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(90)91653-x |
| Popis: | Disk-shedding in the rat retina undergoes a circadian rhythm. Chronic lithium treatment significantly dampens the rhythm in constant darkness, but does not alter the timing or amplitude of the peak in a light-dark cycle. Lithium potentiates light-elicited disk-shedding with a maximal effect at the end of the subjective light phase, when light alone evokes only a moderate response. Although serum lithium levels show a diurnal variation, retinal lithium concentration remains high throughout 24 h. Thus lithium induces alterations in retinal rhythms as well as in photoreceptor metabolism. |
| Databáze: | OpenAIRE |
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