Assessing Immunotherapy with Functional and Molecular Imaging and Radiomics
| Autor: | Teodoro Martín-Noguerol, José Muñoz-Iglesias, Laura Oleaga, Juan Antonio Vallejo Casas, Jordi Broncano, María Carmen Areses, Joan C. Vilanova, Antonio Luna, Sandra Baleato-González, Roberto García-Figueiras |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment MEDLINE 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Radiomics Neoplasms medicine Medical imaging Biomarkers Tumor Tumor Microenvironment Humans Radiology Nuclear Medicine and imaging Medical physics business.industry fungi food and beverages Immunotherapy Genomics Prognosis Cancer treatment Molecular Imaging Phenotype 030220 oncology & carcinogenesis Disease Progression Molecular imaging business |
| Zdroj: | Radiographics : a review publication of the Radiological Society of North America, Inc. 40(7) |
| ISSN: | 1527-1323 |
| Popis: | Immunotherapy is changing the treatment paradigm for cancer and has introduced new challenges in medical imaging. Because not all patients benefit from immunotherapy, pretreatment imaging should be performed to identify not only prognostic factors but also factors that allow prediction of response to immunotherapy. Follow-up studies must allow detection of nonresponders, without confusion of pseudoprogression with real progression to prevent premature discontinuation of treatment that can benefit the patient. Conventional imaging techniques and classic tumor response criteria are limited for the evaluation of the unusual patterns of response that arise from the specific mechanisms of action of immunotherapy, so advanced imaging methods must be developed to overcome these shortcomings. The authors present the fundamentals of the tumor immune microenvironment and immunotherapy and how they influence imaging findings. They also discuss advances in functional and molecular imaging techniques for the assessment of immunotherapy in clinical practice, including their use to characterize immune phenotypes, assess patient prognosis and response to therapy, and evaluate immune-related adverse events. Finally, the development of radiomics and radiogenomics in these therapies and the future role of imaging biomarkers for immunotherapy are discussed. |
| Databáze: | OpenAIRE |
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