Early Enteral Feeding Improves Tolerance of Parenteral Nutrition in Preterm Newborns
| Autor: | Francesco Cresi, Maria Giulia Conti, Salvatore Oliva, Francesca Faccioli, Paola Repole, Maria Di Chiara, Giorgia Deli, Gianluca Terrin, Marco Bianchi, Elisa Onestà, Giovanni Boscarino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
metabolic acidosis
Male Pediatrics Parenteral Nutrition Time Factors Infant Premature Diseases Enteral administration newborn Medicine TX341-641 Prospective Studies trophic feeding Nutrition and Dietetics Gestational age incretin Treatment Outcome Cohort Necrotizing enterocolitis gut Female Acidosis very low birth weight (VLBW) critical condition enteral nutrition feeding intolerance hyperglycemia hypertriglyceridemia necrotizing enterocolitis neonatology very low birth weight (vlbw) acidosis critical illness female gestational age humans infant newborn infant premature infant premature diseases logistic models male metabolic diseases parenteral nutrition prospective studies time factors treatment outcome Infant Premature medicine.medical_specialty Critical Illness Gestational Age Article premature diseases Enteral Nutrition Metabolic Diseases Humans Neonatology business.industry Nutrition. Foods and food supply Postmenstrual Age Infant Newborn Metabolic acidosis medicine.disease infant Parenteral nutrition Logistic Models Hyperglycemia business Food Science |
| Zdroj: | Nutrients Volume 13 Issue 11 Nutrients, Vol 13, Iss 3886, p 3886 (2021) |
| ISSN: | 2072-6643 |
| Popis: | (1) Background: The tolerance of preterm newborns for the high nutritional intakes given by parenteral nutrition (PN) is still debated because of the risk of metabolic complications. Despite enteral nutrition (EN) being the preferred route of nutrition, an exclusive enteral feeding is not always possible, as in preterm newborns, the gut is immature and less tolerant of EN. We aimed to study the impact of a minimal enteral feeding (MEF) on the possible early metabolic complications of PN in a cohort of preterms with gestational age at birth GA ≤ 29 + 6/7 weeks of postmenstrual age. (2) Methods: We divided the study sample in two cohorts: 1) Late-Feeding (cohort 1), newborns who received MEF starting from the 8th day of age, and (2) Early-Feeding (cohort 2), newborns who received MEF, consisting of the administration of at least 4–5 mL/kg/day by the enteral route, in the first 7 days of age. The primary outcome of the study was the rate of at least one metabolic complication, including hyperglycemia, hypertriglyceridemia, or metabolic acidosis. (3) Results: We enrolled 80 newborns (Late-Feeding cohort 51 vs. Early-Feeding cohort 29). The rate of all metabolic complications was statistically higher in the Late-Feeding cohort compared to the Early-Feeding cohort. Binary logistic regression analysis showed that late administration of MEF negatively influenced the rate of all metabolic complications. (4) Conclusions: Early minimal administration of EN is associated with less frequent PN-related metabolic side effects and a higher rate of survival in critically ill newborns. |
| Databáze: | OpenAIRE |
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