Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety
| Autor: | Christian Ritz, Jens F. Rehfeld, Anita Belza, Arne Astrup, Jens J. Holst, Mejse Q Sorensen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Hunger media_common.quotation_subject Appetite Medicine (miscellaneous) Satiation Glucagon Gastrointestinal Hormones Young Adult Double-Blind Method Glucagon-Like Peptide 1 Internal medicine medicine Humans Insulin Peptide YY Cholecystokinin media_common Meal Cross-Over Studies Nutrition and Dietetics Dose-Response Relationship Drug Chemistry digestive oral and skin physiology Pancreatic Hormones Glucagon-like peptide-1 Crossover study Ghrelin Endocrinology Dietary Proteins Energy Intake |
| Zdroj: | The American Journal of Clinical Nutrition. 97:980-989 |
| ISSN: | 0002-9165 0156-1235 |
| DOI: | 10.3945/ajcn.112.047563 |
| Popis: | Background: Effects of protein intake on appetite-regulating hormones and their dynamics are unclear. Objectives: We investigated the satiating effects of meals with varying protein contents and whether there was an effect of dose on appetite-regulating hormones and appetite ratings. Design: Twenty-five men [mean 6 SD age: 30.0 6 8.7 y; body mass index (BMI; in kg/m 2 ): 25.9 6 4.7] participated in the 3-way, randomized, double-blind crossover study. Test meals were isocaloric with 30% of energy from fat and protein content adjusted at the expense of carbohydrate. Test meals were normal protein (NP; 14% of energy from protein), medium-high protein (MHP; 25% of energy from protein), and high protein (HP, 50% of energy from protein). Appetite ratings and blood samples were assessed every 0.5 h for 4 h. An ad libitum lunch was served 4 h after the meal. Results: Protein increased dose-dependently glucagon-like peptide-1 (GLP-1), peptide YY (PYY) 3‐36, and glucagon; MHP produced 10%, 7%, and 47% greater responses, respectively; and HP produced 20%, 14%, and 116% greater responses, respectively, than did NP (P , 0.03). Compared with NP, HP increased insulin and cholecystokinin and decreased ghrelin and glucose-dependent insulinotropic polypeptide (P , 0.05). Satiety and fullness dosedependently increased by 7% and 6% for MHP and 16% and 19% for HP compared with NP (P , 0.001). Hunger and prospective consumption dose-dependently decreased by 15% and 13% for MHP and by 25% and 26% for HP compared with NP (P , 0.0003). There was a combined effect of GLP-1 and PYY 3‐36 (P = 0.03) next to the additive effect of GLP-1 (P =0 .006) on the composite appetite score. No difference was shown in ad libitum energy intake. Conclusion: Protein dose-dependently increased satiety and GLP-1, PYY 3‐36, and glucagon, which may, at least in part, be responsible for the satiety-stimulating effect of protein. This trial was registered at clinicaltrials.gov as NCT01561235. Am J Clin Nutr doi: 10.3945/ajcn.112.047563. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|