Study of TNFα -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population
| Autor: | David Meyre, T. Baroudi, Emanuel Vaillant, Martine Vaxillaire, R. Bouhaha, Vincent Vatin, Philippe Froguel, Rim Sassi, Amel Ben Ammar-El Gaaied, Hafawa Abid, Hajer Ennafaa |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Tunisia Genotype endocrine system diseases Genetic Linkage Clinical Biochemistry Population Single-nucleotide polymorphism Type 2 diabetes Overweight Polymorphism Single Nucleotide Risk Factors Internal medicine medicine Humans SNP Genetic Predisposition to Disease Obesity Genetic variability Promoter Regions Genetic education Genotyping Aged Genetics education.field_of_study Interleukin-6 Tumor Necrosis Factor-alpha business.industry nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Genetics Population Diabetes Mellitus Type 2 Case-Control Studies Female medicine.symptom business |
| Zdroj: | Clinical Biochemistry. 43:549-552 |
| ISSN: | 0009-9120 |
| Popis: | A bstract Objectives We investigated two genetic markers in pro inflammatory molecules : TNFα -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population. Design and methods The study sample includes 228 patients with T2D and 300 healthy controls. Genotyping of IL6 -174G/C (rs1800795) was performed using Automated Dye Terminator Sequencing and of TNFα -308G/A (rs1800629) using the LightTyper technology. Results SNPs IL6 -174G/C and TNFα -308G/A are associated neither with T2D (p = 0.89, p = 0.34 respectively) nor with risk for overweight (p = 0.86, p = 0.12 respectively) in Tunisian population. Bonferroni correction showed that the founded association of IL6 -174G/C SNP with T2D susceptibility restricted to overweight patients (pnominal = 0.03, pcorrected = 0.0033) is likely to be a random result. Conclusion SNPs IL6 -174G/C and TNFα -308G/A are not major contributors to T2D or obesity risk in our Tunisian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect