Structural Abnormalities in Patients with Insular/Peri-insular Epilepsy: Spectrum, Frequency, and Pharmacoresistance
| Autor: | François Guilbert, M.-C. Chevrier, C. Bard, D.K. Nguyen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Peri Drug Resistance Epilepsy Young Adult Atrophy Cortex (anatomy) medicine Humans Radiology Nuclear Medicine and imaging Child Aged Cerebral Cortex Hippocampal sclerosis business.industry Vascular malformation Brain Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Treatment Outcome Gliosis Child Preschool Anticonvulsants Female Neurology (clinical) Abnormality medicine.symptom business |
| Zdroj: | AJNR Am J Neuroradiol |
| Popis: | SUMMARY: Between 2002 and 2010, a total of 48 patients were seen at our epilepsy clinic with insular/peri-insular cortex epilepsy. Review of their MR imaging scans revealed a neoplastic lesion in 27% of patients, a malformation of cortical development in 21%, a vascular malformation in 19%, and atrophy/gliosis from an acquired insult in 17%. MR imaging results were normal in 4 patients. Other miscellaneous findings included a case of Rasmussen encephalitis, a nonspecific insular millimetric T2 signal abnormality, a neuroepithelial cyst, and hippocampal sclerosis without MR imaging evidence of dual insular pathologic features (despite depth electrode–proven insular seizures). Refractoriness to antiepileptic drug treatment was present in 56% of patients: 100% for patients with malformations of cortical development (1.0; 95% CI, 0.72–1.0), 50.0% (0.5; 95% CI, 0.21–0.78) in the presence of atrophy/gliosis from acquired insults, 39% (0.39; 95% CI, 0.14–0.68) for neoplastic lesions, and 22.2% (0.22; 95% CI, 0.06–0.55) for vascular malformations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|