Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas

Autor: Calogero M. Santoro, Vivien G. Standen, Wolfgang Haak, Ilán Santiago Leboreiro Reyna, Julien Soubrier, Simon Y. W. Ho, Maria Inés Barreto Romero, Cristina Valdiosera, Guido Valverde, Richard L. Burger, Lucía Watson Jiménez, Colin Smith, David Reich, Julio Alejandro Ballivián Torrez, Adam Ben Rohrlach, Elsa Tomasto Cagigao, Alan Cooper, Isabel Flores Espinoza, Mario A. Rivera, R. Spencer Wells, Krzysztof Makowski, Lars Fehren-Schmitz, Nadin Rohland, Gustavo G. Politis, María Constanza Ceruti, Bastien Llamas, Stephen M. Richards, Susanne Nordenfelt, Johan Reinhard, Josefina Mansilla Lory, Swapan Mallick
Rok vydání: 2016
Předmět:
0301 basic medicine
Pre-Columbian
01 natural sciences
Coalescent theory
Indians
Chile
Research Articles
Native America
Phylogeny
Uncategorized
education.field_of_study
Genome
Multidisciplinary
purl.org/becyt/ford/5 [https]
Ancient DNA
Ecology
SciAdv r-articles
Emigration and Immigration
Mitochondrial
Archaeology
purl.org/becyt/ford/5.9 [https]
North American
Research Article
010506 paleontology
Mitochondrial DNA
Pleistocene
Population
Biology
DNA
Mitochondrial
Beringia
Ancient
CIENCIAS SOCIALES
03 medical and health sciences
Genetics
Humans
DNA
Ancient
education
Peopling
0105 earth and related environmental sciences
Genetic diversity
Genetic Variation
Bayes Theorem
DNA
South America
colonization
Phylogeography
030104 developmental biology
Genetics
Population
Haplotypes
Otras Ciencias Sociales
Evolutionary biology
Anthropology
Genome
Mitochondrial
Indians
North American
Americas
Zdroj: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Science Advances
Science advances, vol 2, iss 4
Popis: Native American population history is reexamined using a large data set of pre-Columbian mitochondrial genomes.
The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages.
Databáze: OpenAIRE
Externí odkaz: