Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study
| Autor: | Mats Christian Højbjerg Lassen, Jacob Louis Marott, Morten Sengeløv, Peter Schnohr, Peter Søgaard, Rasmus Mogelvang, Tor Biering-Sørensen, Gorm B. Jensen, Niklas Dyrby Johansen, Anne Bjerg Nielsen, Lisa Steen Duus, Raphael Hauser, Kristoffer Grundtvig Skaarup |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Longitudinal study Population Left atrial strain Risk Assessment two-dimensional speckle-tracking echocardiography Left atrial Internal medicine Atrial Fibrillation medicine Clinical endpoint Humans atrial fibrillation Radiology Nuclear Medicine and imaging Heart Atria Longitudinal Studies Prospective Studies LACS education PACS education.field_of_study business.industry Hazard ratio Atrial fibrillation General Medicine medicine.disease Confidence interval PALS Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Hauser, R, Nielsen, A B, Skaarup, K G, Lassen, M C H, Duus, L S, Johansen, N D, Sengeløv, M, Marott, J L, Jensen, G, Schnohr, P, Søgaard, P, Møgelvang, R & Biering-Sørensen, T 2022, ' Left atrial strain predicts incident atrial fibrillation in the general population : the Copenhagen City Heart Study ', European Heart Journal Cardiovascular Imaging, vol. 23, no. 1, pp. 52–60 . https://doi.org/10.1093/ehjci/jeab202 Hauser, R, Nielsen, A B, Skaarup, K G, Lassen, M C H, Duus, L S, Johansen, N D, Sengeløv, M, Marott, J L, Jensen, G, Schnohr, P, Søgaard, P, Møgelvang, R & Biering-Sørensen, T 2022, ' Left atrial strain predicts incident atrial fibrillation in the general population : the Copenhagen City Heart Study ', European Heart Journal Cardiovascular Imaging, vol. 23, no. 1, pp. 52-60 . https://doi.org/10.1093/ehjci/jeab202 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeab202 |
| Popis: | Background Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of atrial fibrillation (AF) in several patient cohorts. The purpose of this study was to investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can be used to predict the development of AF in the general population. Methods and results This prospective longitudinal study included 4466 participants from the fifth Copenhagen City Heart Study. All participants underwent a health examination, including echocardiographic measurements of LA strain. Participants with prevalent AF at baseline were excluded. The primary endpoint was incident AF. During a median follow-up period of 5.3 years, 154 (4.3%) participants developed AF. In univariable analysis, peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase were significantly associated with the development of AF. PALS [hazard ratio (HR) 1.05, 95% confidence interval (CI) (1.03–1.07), P Conclusion In the general population, PALS and PACS independently predict incident AF. These findings remained consistent even in participants with normal-sized LA and normal LV systolic function. |
| Databáze: | OpenAIRE |
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