Towards a miniaturized brain-machine-spinal cord interface (BMSI) for restoration of function after spinal cord injury
| Autor: | Scott Barbay, Gustaf M. Van Acker, Shawn B. Frost, Pedram Mohseni, Stacey L. DeJong, Shahab Shahdoost, Randolph J. Nudo, Caleb Dunham |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Nervous system Cord business.industry Movement Recovery of Function medicine.disease Spinal cord Hindlimb Rats medicine.anatomical_structure Cerebral cortex Brain-Computer Interfaces Paralysis Animals Medicine Microstimulation medicine.symptom business Neuroscience Spinal cord injury Spinal Cord Injuries Brain–computer interface |
| Zdroj: | EMBC |
| Popis: | Nearly 6 million people in the United States are currently living with paralysis in which 23% of the cases are related to spinal cord injury (SCI). Miniaturized closed-loop neural interfaces have the potential for restoring function and mobility lost to debilitating neural injuries such as SCI by leveraging recent advancements in bioelectronics and a better understanding of the processes that underlie functional and anatomical reorganization in an injured nervous system. This paper describes our current progress towards developing a miniaturized brain-machine-spinal cord interface (BMSI) that is envisioned to convert in real time the neural command signals recorded from the brain to electrical stimuli delivered to the spinal cord below the injury level. Specifically, the paper reports on a corticospinal interface integrated circuit (IC) as a core building block for such a BMSI that is capable of low-noise recording of extracellular neural spikes from the cerebral cortex as well as muscle activation using intraspinal microstimulation (ISMS) in a rat with contusion injury to the thoracic spinal cord. The paper further presents results from a neurobiological study conducted in both normal and SCI rats to investigate the effect of various ISMS parameters on movement thresholds in the rat hindlimb. Coupled with proper signal-processing algorithms in the future for the transformation between the cortically recorded data and ISMS parameters, such a BMSI has the potential to facilitate functional recovery after an SCI by re-establishing corticospinal communication channels lost due to the injury. |
| Databáze: | OpenAIRE |
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