Innovative Burn Treatment Using Tilapia Skin as a Xenograft: A Phase II Randomized Controlled Trial
| Autor: | Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Ana Paula Negreiros Nunes Alves, Edmar Maciel Lima Júnior, Bruno Almeida Costa, Marina Becker Sales Rocha, Monica Beatriz Mathor, Antonio J. Forte, Francisco Vagnaldo Fechine, Camila Barroso Martins, Andrea Vieira Pontes Rohleder, Francisco Raimundo Silva Júnior |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Visual analogue scale Body Surface Area Occlusive Dressings Silver sulfadiazine law.invention 03 medical and health sciences Nile tilapia 0302 clinical medicine Sulfadiazine Randomized controlled trial law medicine Animals Humans Pain Measurement Skin Artificial integumentary system biology business.industry Rehabilitation 030208 emergency & critical care medicine 030206 dentistry biology.organism_classification Occlusive dressing Clinical trial Oreochromis Anesthesia Emergency Medicine Heterografts Surgery Female business Burns human activities Brazil medicine.drug Tilapia |
| Zdroj: | Journal of burn careresearch : official publication of the American Burn Association. 41(3) |
| ISSN: | 1559-0488 |
| Popis: | Skin substitutes are considered a useful alternative for occlusive dressings in the treatment of superficial burns as they reduce the frequency of dressing replacement. This phase II randomized controlled trial aimed to evaluate the efficacy of Nile tilapia (Oreochromis niloticus) skin as an occlusive xenograft dressing for the treatment of burn wounds in humans. In order to assess the use of tilapia skin, the following variables were evaluated: number of days for wound healing, the number of times the occlusive dressing was changed, use of anesthetics or analgesics, pain assessment using the Visual Analogue Scale, and evaluation of burn improvement on the day of dressing removal. In total, 62 participants completed the study. It was found that in participants treated with tilapia skin, complete reepithelialization occurred in significantly fewer days; reported pain intensity was lower (study arms B and C), the amount of anesthetics/analgesics required was lower (study arms B and C), and the necessity of dressing changes was significantly reduced in comparison with volunteers treated with silver sulfadiazine. In our study, the tilapia skin xenograft showed good efficacy as an occlusive biological dressing for burn wound treatment in humans. |
| Databáze: | OpenAIRE |
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