Preliminary evidence for gender effects of levetiracetam monotherapy duration on bone health of patients with epilepsy
| Autor: | Anastasia Bougea, Nikolaos Triantafyllou, Irene Lambrinoudaki, Stergios Gatzonis, Artemios Artemiadis, Panagiota Voskou, Sotiris Giannopoulos, Georgios Tsivgoulis, Apostolos Safouris |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Levetiracetam Health Status Osteoporosis 030209 endocrinology & metabolism Bone health Drug Administration Schedule Cohort Studies 03 medical and health sciences Behavioral Neuroscience Epilepsy Young Adult 0302 clinical medicine Bone Density Internal medicine medicine Humans Adverse effect Femoral neck Retrospective Studies Bone mineral Sex Characteristics Lumbar Vertebrae business.industry Middle Aged medicine.disease Piracetam Surgery Osteopenia Radiography medicine.anatomical_structure Treatment Outcome Neurology Anticonvulsants Female Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Epilepsybehavior : EB. 55 |
| ISSN: | 1525-5069 |
| Popis: | Enzyme-inducing antiepileptic drugs AEDs have adverse effects on bone mineral density (BMD), whereas studies on levetiracetam (LEV), a nonenzyme-inducing agent, have showed conflicting results. The aim of this study was to further elucidate the role of LEV in bone health. A sample of forty-six patients with epilepsy (mean age: 35.7 years, range: 20.2-64.2 years, 39.1% males) on LEV monotherapy for at least one year (range: 1.5-14.5 years, median 5.5 years) underwent femoral neck (FN) and lumbar spine (LS) BMD measurements. The T- and Z-scores were calculated. Results showed that 15.2% of the patients were identified with osteopenia and none with osteoporosis. Pearson's correlations revealed a negative but not significant association of LEV duration with bone-related measurements (range of rhos: from -0.004 to -0.23), except for LS T-scores. In terms of FN BMD measurements, Z-scores, and T-scores, longer LEV therapy duration had adverse but not significant effects on bone health after adjusting for age and gender. With regard to LS BMD measurements, Z-scores, and T-scores, men taking LEV for at least 5.5 years had better, although not significant, bone health compared with men with shorter LEV exposure, after adjusting for age. The opposite was found in women, although differences did not reach significance. These preliminary results are indicative of a differential effect of LEV therapy duration in men and women, which could presumably account for the incongruity of the already published studies. Also, LS assessments were more sensitive to these gender differences. Future larger studies should validate these results. |
| Databáze: | OpenAIRE |
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