Meloxicam quantification in rabbit plasma by RP-HPLC: optimization and application to pharmacokinetic study
| Autor: | Nitin Salunkhe, Namdeo R. Jadhav, Somnath D. Bhinge |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Detection limit
Bioanalysis Chromatography medicine.diagnostic_test Chemistry lcsh:RM1-950 lcsh:RS1-441 Lornoxicam Bioequivalence Rabbit Plasma Meloxicam Pharmacokinetic Study Bioavailability lcsh:Pharmacy and materia medica lcsh:Therapeutics. Pharmacology Pharmacokinetics Therapeutic drug monitoring Validation medicine medicine.drug |
| Zdroj: | Future Journal of Pharmaceutical Sciences, Vol 6, Iss 1, Pp 1-12 (2020) |
| ISSN: | 2314-7253 |
| Popis: | Background The goal of the proposed study was to validate a rapid, simple, an accurate, robust, and sensitive bioanalytical method for quantifying Meloxicam and Lornoxicam (as internal standard) in rabbit plasma. Result Limit of detection and limit of quantification for Meloxicam were found to be 0.0081 and 0.1035 μg mL−1, respectively. The bioanalysis was continued according to standard guidelines and successfully used for bioavailability studies of meloxicam after single dose administration of pure drug and the formulation in rabbit plasma. Finally, obtained results proved its simplicity and an efficiency to be applied for the therapeutic drug monitoring and bioequivalence studies. Conclusion Therefore, the set RP-HPLC bioanalysis is simple, convenient, and acceptable to analyze meloxicam in bulk and pharmaceutical formulations in rabbit plasma. Graphical abstract |
| Databáze: | OpenAIRE |
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