Force of lifelong crystalline lens growth: chronic traumatic mechanical insult to the choroid
| Autor: | Liliana Werner, Kenneth Lu, Suqin Guo, Lawrence M Strenk, Susan A. Strenk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure Aging genetic structures Glaucoma Cataract Article Cataracts Ophthalmology Lens Crystalline medicine Humans Aged Retrospective Studies Aged 80 and over Retina Choroid Diabetic retinopathy Uvea Macular degeneration Middle Aged medicine.disease eye diseases Sensory Systems medicine.anatomical_structure Surgery sense organs |
| Zdroj: | J Cataract Refract Surg |
| ISSN: | 1873-4502 |
| Popis: | Purpose To calculate the forces applied to uvea and retina as a result of lifelong crystalline lens growth. Design Retrospective Study. Setting MRI Research, Inc., Middleburg Heights, Ohio, USA; Institute of Ophthalmology and Visual Science UMDNJ-New Jersey Medical School, Newark, New Jersey; USC Psychology University of Southern California, Los Angeles CA. Methods Magnetic resonance images were acquired from 15 phakic/pseudophakic eye pairs in cataract patients (ages 46-83). Choroidal lengths were measured. The forces required to produce differences between phakic/pseudophakic choroidal lengths were calculated. Results The length of the choroid is greater in the phakic eye compared to the corresponding pseudophakic eye and this difference increases with age (P = 0.00006; power = 0.99). The corresponding choroidal strain also increases with age (P = 0.00003, power = 0.99) as do the forces required to produce such a change in choroidal length (P=0.000008, power = 0.99). Conclusions We theorize that lifelong crystalline lens growth applies a chronic, traumatic, mechanical insult to the uvea and retina. This previously unknown, ever-increasing, force appears to stretch the choroidal tissue and may be an intraocular pressure independent modifiable risk factor for retinal disease. Implications exist for understanding the pathophysiology of retinal diseases in the aging eye that are often co-morbid with cataracts, for example, glaucoma, macular degeneration and diabetic retinopathy. |
| Databáze: | OpenAIRE |
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