Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure
| Autor: | Kenji Yoshioka, Takashi Naruke, Shogo Oishi, Tatsuya Miyoshi, Nobuyuki Kagiyama, Kazuki Yoshida, Shunsuke Kuroda, Takeshi Kitai, Satoshi Suzuki, Keisuke Kida, Takahiro Okumura, Yuichi Baba, Eiichi Akiyama, Masayoshi Yamamoto, Yuya Matsue, Atsushi Mizuno, Kazuo Mizutani, Yasutaka Inuzuka, Kota Kato, Ryuichi Matsukawa, Tetsuo Yamaguchi |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Scoring system 030204 cardiovascular system & hematology Severity of Illness Index 03 medical and health sciences Liver disease 0302 clinical medicine Albumins Internal medicine medicine Humans In patient Prospective Studies 030212 general & internal medicine Aged Heart Failure Prothrombin time Framingham Risk Score medicine.diagnostic_test business.industry Bilirubin Emergency department Prognosis medicine.disease ROC Curve Creatinine Heart failure Acute Disease Female Liver function Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | Heart, Lung and Circulation. 29:1328-1337 |
| ISSN: | 1443-9506 |
| DOI: | 10.1016/j.hlc.2019.12.003 |
| Popis: | Although liver dysfunction is one of the common complications in patients with acute heart failure (AHF), no integrated marker has been defined. The albumin-bilirubin (ALBI) score has recently been proposed as a novel, clinically-applicable scoring system for liver dysfunction. We investigated the utility of the ALBI score in patients with AHF compared to that for a preexisting liver dysfunction score, the Model of End-Stage Liver Disease Excluding prothrombin time (MELD XI) score.We evaluated ALBI and MELD XI scores in 1,190 AHF patients enrolled in the prospective, multicentre Registry Focused on Very Early Presentation and Treatment in Emergency Department of Acute Heart Failure study. The associations between the two scores and the clinical profile and prognostic predictive ability for 1-year mortality were evaluated.The mean MELD XI and ALBI scores were 13.4±4.8 and -2.25±0.48, respectively. A higher ALBI score, but not higher MELD XI score, was associated with findings of fluid overload. After adjusting for pre-existing prognostic factors, the ALBI score (HR 2.11, 95% CI: 1.60-2.79, p0.001), but not the MELD XI score (HR 1.02, 95% CI: 0.99-1.06, p=0.242), was associated with 1-year mortality. Likewise, area under the receiver-operator-characteristic curves for 1-year mortality significantly increased when the ALBI score (0.71 vs. 0.74, p=0.020), but not the MELD XI score (0.71 vs. 0.72, p=0.448), was added to the pre-existing risk factors.The ALBI score is potentially a suitable liver dysfunction marker that incorporates information on fluid overload and prognosis in patients with AHF. These results provide new insights into heart-liver interactions in AHF patients. |
| Databáze: | OpenAIRE |
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