Chemopreventive effects of Cuminum cyminum in chemically induced forestomach and uterine cervix tumors in murine model systems
| Autor: | Ester. Mendiz, Sivanandhan Dhanalakshmi, Raosaheb K. Kale, Gagandeep, Agra Ramesha Rao |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Cuminum Antioxidant medicine.medical_treatment Glutathione reductase Medicine (miscellaneous) Uterine Cervical Neoplasms Pharmacology Lipid peroxidation chemistry.chemical_compound Mice Random Allocation Cytochrome P-450 Enzyme System Stomach Neoplasms Lactate dehydrogenase medicine Animals Anticarcinogenic Agents Anticarcinogen Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Nutrition and Dietetics biology Dose-Response Relationship Drug business.industry Plant Extracts Superoxide Dismutase Glutathione peroxidase Glutathione biology.organism_classification Diet Oxidative Stress Glutathione Reductase Oncology chemistry Liver Female Lipid Peroxidation business Phytotherapy |
| Zdroj: | Nutrition and cancer. 47(2) |
| ISSN: | 0163-5581 |
| Popis: | Lately, a strong correlation has been established between diet and cancer. For ages, cumin has been a part of the diet. It is a popular spice regularly used as a flavoring agent in a number of ethnic cousins. In the present study, cancer chemopreventive potentials of different doses of a cumin seed-mixed diet were evaluated against benzo(a)pyrene [B(a)P]-induced forestomach tumorigenesis and 3-methylcholanthrene (MCA)-induced uterine cervix tumorigenesis. Results showed a significant inhibition of stomach tumor burden (tumors per mouse) by cumin. Tumor burden was 7.33 +/- 2.10 in the B(a)P-treated control group, whereas it reduced to 3.10 +/- 0.57 (P < 0.001) by a 2.5% dose and 3.11 +/- 0.60 (P |
| Databáze: | OpenAIRE |
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