Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2
| Autor: | Zixi Yin, Tao Dong, Dannielle Wellington, Benedikt M. Kessler |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antigen Presentation
Proteasome Endopeptidase Complex Immunodominant Epitopes SARS-CoV-2 T-Lymphocytes viruses T cell Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Antigen presentation Receptors Antigen T-Cell Context (language use) Immunodominance Computational biology biochemical phenomena metabolism and nutrition Biology Article Epitope Cytosol medicine.anatomical_structure Immune system Virology medicine Humans CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Current Opinion in Virology |
| ISSN: | 1879-6257 |
| Popis: | Immunodominance is a complex and highly debated topic of T cell biology. The current SARS-CoV-2 pandemic has provided the opportunity to profile adaptive immune responses and determine molecular factors contributing to emerging responses towards immunodominant viral epitopes. Here, we discuss parameters that alter the dynamics of CD8 viral epitope processing, generation and T-cell responses, and how immunodominance counteracts viral immune escape mechanisms that develop in the context of emerging SARS-CoV-2 variants. |
| Databáze: | OpenAIRE |
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