Placebo- and paracetamol-controlled study on the efficacy and tolerability of hyoscine butylbromide in the treatment of patients with recurrent crampy abdominal pain
| Autor: | Guido N. J. Tytgat, Eamonn Martin Quigley, Eckhard Schaefer, Hubertus Peil, J. Bubeck, L. G. Paulo, S. Mueller-Lissner |
|---|---|
| Přispěvatelé: | Extramural researchers |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Abdominal pain Adolescent Visual analogue scale Analgesic Placebo law.invention Randomized controlled trial Recurrence law Butylscopolammonium Bromide medicine Humans Pharmacology (medical) Adverse effect Acetaminophen Aged Hepatology business.industry Gastroenterology Analgesics Non-Narcotic Middle Aged Abdominal Pain Treatment Outcome Tolerability Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | Alimentary pharmacology & therapeutics, 23(12), 1741-1748. Wiley-Blackwell |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.2006.02818.x |
| Popis: | ummary Aim To compare the efficacy and tolerability of oral hyoscine butylbromide (hereafter hyoscine) 10 mg t.d.s., paracetamol 500 mg t.d.s. and their fixed combination against placebo in patients with recurrent crampy abdominal pain. Methods A total of 1637 patients were entered into a four-arm double-blind study. After a 1 week placebo run-in, they were randomized to 3 weeks of treatment with one of the four therapies with assessments after 1, 2 and 3 weeks. Pain intensity (Visual Analogue Scale) and pain frequency (Verbal Rating Scale) were self-assessed daily. Results Pain intensity on the Visual Analogue Scale decreased in all treatment groups; the adjusted mean changes from baseline were 2.3, 2.4 and 2.4 cm for the hyoscine, paracetamol and combination groups, respectively, compared with 1.9 cm for the placebo group (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |