Age-related macular degeneration changes the processing of visual scenes in the brain
| Autor: | Carole Peyrin, Louise Kauffmann, Sylvie Chokron, R. Hera, Stephen Ramanoël, Christophe Chiquet, Alexandre Krainik |
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| Přispěvatelé: | Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service d'Ophtalmologie [Grenoble], Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Centre Hospitalier Universitaire de Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Physiology media_common.quotation_subject Normalization (image processing) [SHS.PSY]Humanities and Social Sciences/Psychology Audiology Luminance 050105 experimental psychology Retina 03 medical and health sciences 0302 clinical medicine Spatial Processing Perception Age related medicine Humans 0501 psychology and cognitive sciences media_common Aged Brain Mapping business.industry 05 social sciences Occipital cortex Exudates and Transudates Macular degeneration Contrast Parahippocampal place area Middle Aged medicine.disease Magnetic Resonance Imaging Sensory Systems eye diseases Categorization Spatial frequency Visual Perception Wet Macular Degeneration Low spatial frequency [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female sense organs Occipital Lobe Visual Fields business 030217 neurology & neurosurgery Tomography Optical Coherence |
| Zdroj: | Visual Neuroscience Visual Neuroscience, Cambridge University Press (CUP), 2018, 35, pp.E006. ⟨10.1017/S0952523817000372⟩ |
| ISSN: | 1469-8714 0952-5238 |
| DOI: | 10.1017/S0952523817000372⟩ |
| Popis: | In age-related macular degeneration (AMD), the processing of fine details in a visual scene, based on a high spatial frequency processing, is impaired, while the processing of global shapes, based on a low spatial frequency processing, is relatively well preserved. The present fMRI study aimed to investigate the residual abilities and functional brain changes of spatial frequency processing in visual scenes in AMD patients. AMD patients and normally sighted elderly participants performed a categorization task using large black and white photographs of scenes (indoors vs. outdoors) filtered in low and high spatial frequencies, and nonfiltered. The study also explored the effect of luminance contrast on the processing of high spatial frequencies. The contrast across scenes was either unmodified or equalized using a root-mean-square contrast normalization in order to increase contrast in high-pass filtered scenes. Performance was lower for high-pass filtered scenes than for low-pass and nonfiltered scenes, for both AMD patients and controls. The deficit for processing high spatial frequencies was more pronounced in AMD patients than in controls and was associated with lower activity for patients than controls not only in the occipital areas dedicated to central and peripheral visual fields but also in a distant cerebral region specialized for scene perception, the parahippocampal place area. Increasing the contrast improved the processing of high spatial frequency content and spurred activation of the occipital cortex for AMD patients. These findings may lead to new perspectives for rehabilitation procedures for AMD patients. |
| Databáze: | OpenAIRE |
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