Central melanocortins regulate the motivation for sucrose reward
| Autor: | Pandit, Rahul, van der Zwaal, Esther M, Luijendijk, Mieneke C M, Brans, Maike A D, van Rozen, Andrea J, Oude Ophuis, Ralph J A, Vanderschuren, Louk J M J, Adan, Roger A H, la Fleur, Susanne E, Sub Neurobiologie van gedrag, ASS E&C1, Emotion and Cognition |
|---|---|
| Přispěvatelé: | Nuclear Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ANS - Amsterdam Neuroscience, Endocrinology, Endocrinology Laboratory, Sub Neurobiologie van gedrag, ASS E&C1, Emotion and Cognition |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Agonist
Central Nervous System Male medicine.medical_specialty Sucrose medicine.drug_class lcsh:Medicine Nucleus accumbens Biology Research Support Biochemistry Nucleus Accumbens Reward Dopamine Internal medicine medicine Journal Article Animals Agouti-Related Protein Rats Wistar lcsh:Science Receptor Non-U.S. Gov't Melanocortins Medicine(all) Motivation Multidisciplinary Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) Research Support Non-U.S. Gov't lcsh:R digestive oral and skin physiology Feeding Behavior Ventral tegmental area Endocrinology medicine.anatomical_structure alpha-MSH Receptor Melanocortin Type 4 lcsh:Q Melanocortin Agouti-related peptide hormones hormone substitutes and hormone antagonists medicine.drug Genetics and Molecular Biology(all) Receptor Melanocortin Type 3 Signal Transduction Research Article |
| Zdroj: | PLoS ONE [E], 10(3). Public Library of Science PLoS ONE PLoS ONE, 10(3). Public Library of Science PLoS ONE, Vol 10, Iss 3, p e0121768 (2015) PLoS One, 10(3). Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | The role of the melanocortin (MC) system in feeding behavior is well established. Food intake is potently suppressed by central infusion of the MC 3/4 receptor agonist α-melanocyte stimulating hormone (α-MSH), whereas the MC 3/4 receptor inverse-agonist Agouti Related Peptide (AGRP) has the opposite effect. MC receptors are widely expressed in both hypothalamic and extra-hypothalamic brain regions, including nuclei involved in food reward and motivation, such as the nucleus accumbens (NAc) and the ventral tegmental area. This suggests that MCs modulate motivational aspects of food intake. To test this hypothesis, rats were injected intracerebroventricularly with α-MSH or AGRP and their motivation for sucrose was tested under a progressive ratio schedule of reinforcement. Food motivated behavior was dose-dependently decreased by α-MSH. Conversely, AGRP increased responding for sucrose, an effect that was blocked by pretreatment with the dopamine receptor antagonist α-flupenthixol. In contrast to progressive ratio responding, free intake of sucrose remained unaltered upon α-MSH or AGRP infusion. In addition, we investigated whether the effects of α-MSH and AGRP on food motivation were mediated by the NAc shell. In situ hybridization of MC3 and MC4 receptor expression confirmed that the MC4 receptor was expressed throughout the NAc, and injection of α-MSH and AGRP into the NAc shell caused a decrease and an increase in motivation for sucrose, respectively. These data show that the motivation for palatable food is modulated by MC4 receptors in the NAc shell, and demonstrate cross-talk between the MC and dopamine system in the modulation of food motivation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|