Effect of coenzyme Q10 supplementation on cardiac hypertrophy of male rats consuming a high-fructose, low-copper diet
| Autor: | Meira Fields, Willard A. Burns, Mark D. Lure, Charles G. Lewis |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Ubiquinone Endocrinology Diabetes and Metabolism Clinical Biochemistry Coenzymes Weanling Cardiomegaly Fructose Biology Biochemistry Muscle hypertrophy Inorganic Chemistry Rats Sprague-Dawley chemistry.chemical_compound Oral administration Fibrosis Internal medicine medicine Dietary Carbohydrates Animals Coenzyme Q10 Myocardium Biochemistry (medical) Heart General Medicine medicine.disease Diet Rats Microscopy Electron Endocrinology chemistry Copper deficiency Copper |
| Zdroj: | Biological trace element research. 37(2-3) |
| ISSN: | 0163-4984 |
| Popis: | Administration of coenzyme Q10 to humans and animals has a beneficial effect on a number of cardiac diseases. The purpose of the present study was to determine if coenzyme Q10 treatment could ameliorate cardiac abnormalities associated with the carbohydrate x copper interaction in rats. Weanling male rats were provided with a copper-deficient diet (0.6 microgram Cu/g) containing either 62.7% starch (S-Cu) or fructose (F-Cu) for 5 wk. Half of the rats provided with the F-Cu diet were given daily oral supplements of 300 mg coenzyme Q10/kg body weight (F-Cu + Q). Heart hypertrophy, liver enlargement, or pancreatic atrophy were not affected by, nor was body growth or anemia improved by, supplementation with coenzyme Q10 when compared to rats fed only the F-Cu diet. Hearts from rats fed the F-Cu diet had severe inflammation, degeneration, fibrosis, and giant mitochondria with abnormal cristae. Hearts from F-Cu + Q rats had similar mitochondrial changes as the F-Cu rat hearts but without any apparent degenerative changes. None of the F-Cu + Q rats, but 30% of the F-Cu rats, died during the study as a result of heart rupture. These observations show that whereas coenzyme Q10 treatment did not prevent the cardiac hypertrophy of the carbohydrate x copper interaction, it did play a role in maintaining the integrity of the heart. |
| Databáze: | OpenAIRE |
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