Design and demonstration of an intracortical probe technology with tunable modulus
| Autor: | Walter Voit, Robert L. Rennaker, Tong Kang, Conan St. John, Andrew M. Sloan, Joseph J. Pancrazio, Theodore C. Dumas, David Arreaga-Salas, Hamid Charkhkar, Dustin Simon, Daniel G. McHail, Dane W. Grasse, Gretchen L. Knaack, Radu Reit, Sakthi Rajendran |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Semiconductor device fabrication Biomedical Engineering Modulus 02 engineering and technology Brain tissue Article Biomaterials Mice 03 medical and health sciences 0302 clinical medicine Elastic Modulus Animals Electrodes Softening Device failure chemistry.chemical_classification Metals and Alloys Polymer 021001 nanoscience & nanotechnology Brain Waves Frontal Lobe Microelectrode Shape-memory polymer chemistry Ceramics and Composites 0210 nano-technology 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | J Biomed Mater Res A |
| ISSN: | 1552-4965 1549-3296 |
| DOI: | 10.1002/jbm.a.35896 |
| Popis: | Intracortical probe technology, consisting of arrays of microelectrodes, offers a means of recording the bioelectrical activity from neural tissue. A major limitation of existing intracortical probe technology pertains to limited lifetime of 6 months to a year of recording after implantation. A major contributor to device failure is widely believed to be the interfacial mechanical mismatch of conventional stiff intracortical devices and the surrounding brain tissue. We describe the design, development, and demonstration of a novel functional intracortical probe technology that has a tunable Young's modulus from ∼2 GPa to ∼50 MPa. This technology leverages advances in dynamically softening materials, specifically thiol-ene/acrylate thermoset polymers, which exhibit minimal swelling of |
| Databáze: | OpenAIRE |
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