Predicting progression of amnesic MCI: The integration of episodic memory impairment with perfusion SPECT

Autor: Carlo Masullo, Davide Quaranta, Guido Gainotti, Camillo Marra, Giordano Lacidogna, Maria Gabriella Vita, Valeria Guglielmi, Alessandro Giordano, Fabrizio Cocciolillo, Daniela Di Giuda
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Amnesic Mild Cognitive Impairment
Audiology
Neuropsychological Tests
Alzheimer's Disease
0302 clinical medicine
Nuclear Medicine and Imaging
(99m)Tc-HMPAO-SPECT hypoperfusion
Conversion to dementia
Episodic memory score
Posterior Cingulate Cortex
Prospective Studies
Episodic memory
Long-term memory
Neuropsychology
Middle Aged
Verbal Learning
Psychiatry and Mental health
Settore MED/26 - NEUROLOGIA
99 mTc-HMPAO-SPECT hypoperfusion
Neuroscience (miscellaneous)
Radiology
Nuclear Medicine and Imaging
Psychiatry and Mental Health
Disease Progression
Female
medicine.symptom
Radiology
Psychology
medicine.medical_specialty
Memory
Episodic
Amnesia
Verbal learning
behavioral disciplines and activities
Gyrus Cinguli
03 medical and health sciences
Predictive Value of Tests
mental disorders
medicine
Dementia
Humans
Radiology
Nuclear Medicine and imaging
Cognitive Dysfunction
Psychiatry
Aged
Tomography
Emission-Computed
Single-Photon
Recall
medicine.disease
030104 developmental biology
Posterior cingulate
Mental Recall
030217 neurology & neurosurgery
Zdroj: Psychiatry research. Neuroimaging. 271
ISSN: 1872-7506
Popis: The present study aimed at assessing if the ability to predict progression from amnesic Mild Cognitive Impairment (aMCI) to dementia is improved by considering the presence at the baseline of Single Photon Emission Computed Tomography (SPECT) perfusion abnormalities in addition to a defect of long term memory. The Episodic Memory Score (EMS), a global index which integrates results obtained in subtests of the Rey's Verbal Learning Test and the Rey-Osterrieth Figure recall, were taken into account to evaluate defects of long term memory. The study sample consisted of 42 subjects affected by aMCI, who were followed-up during a two-year period. At the final follow-up 15 subjects progressed to AD. The EMS predicted progression from aMCI to dementia with a high level of sensitivity and a lower level of specificity, but the association of neuropsychological (EMS) and SPECT data (hypoperfusion in the Posterior Cingulate Cortex) increased the accuracy in predicting conversion from aMCI to AD. The association of results obtained by aMCI patients on memory tests and perfusion SPECT may improve the accuracy in detecting subjects who will progress to dementia. The use of currently available and low-cost investigations could be advantageous in terms of public health policies.
Databáze: OpenAIRE
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