Mechanisms of Notch signaling: a simple logic deployed in time and space
| Autor: | François Schweisguth, Domingos Henrique |
|---|---|
| Přispěvatelé: | Instituto de Medicina Molecular (iMM), Faculdade de Medicina [Lisboa], Universidade de Lisboa (ULISBOA)-Universidade de Lisboa (ULISBOA), Instituto de Histologia e Biologia do Desenvolvimento [Lisboa, Portugal] (IHBD), Génétique du Développement de la Drosophile, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Our research received specific grants from the Agence Nationale de la Recherche (ANR16-CE13-0003-02 and ANR-10-LABX-0073) and Fondation pour la Recherche Médicale (DEQ201180339219) to F.S., We thank A. Bardin, K. Storey, M. Trylinski and our anonymous referees for useful comments and suggestions. We thank F. Corson for Fig. 5., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Repositório da Universidade de Lisboa, Universidade de Lisboa = University of Lisbon (ULISBOA)-Universidade de Lisboa = University of Lisbon (ULISBOA), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Notch
Notch signaling pathway MESH: Receptors Notch/genetics Biology Cell fate determination 03 medical and health sciences 0302 clinical medicine Animals Humans MESH: Animals Molecular Biology [SDV.BDD]Life Sciences [q-bio]/Development Biology 030304 developmental biology 0303 health sciences Stem cell MESH: Humans Receptors Notch Mechanism (biology) Signaling MESH: Signal Transduction Patterning MESH: Receptors Notch/metabolism Cell fate Neuroscience 030217 neurology & neurosurgery Function (biology) Developmental Biology Signal Transduction |
| Zdroj: | Development (Cambridge, England) Development (Cambridge, England), Company of Biologists, 2019, 146 (3), pp.dev172148. ⟨10.1242/dev.172148⟩ Development (Cambridge, England), 2019, 146 (3), pp.dev172148. ⟨10.1242/dev.172148⟩ |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.172148⟩ |
| Popis: | © 2019. Published by The Company of Biologists. All rights reserved. Most cells in our body communicate during development and throughout life via Notch receptors and their ligands. Notch receptors relay information from the cell surface to the genome via a very simple mechanism, yet Notch plays multiple roles in development and disease. Recent studies suggest that this versatility in Notch function may not necessarily arise from complex and context-dependent integration of Notch signaling with other developmental signals, but instead arises, in part, from signaling dynamics. Here, we review recent findings on the core Notch signaling mechanism and discuss how spatial-temporal dynamics contribute to Notch signaling output. Our research received specific grants from the Agence Nationale de la Recherche (ANR16-CE13-0003-02 and ANR-10-LABX-0073) and Fondation pour la Recherche Mé dicale (DEQ201180339219) to F.S |
| Databáze: | OpenAIRE |
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