In prenatally diagnosed CPAM, does the affected lobe influence the timing of symptom onset?
Autor: | Go Miyano, Soichi Shibuya, Atsuyuki Yamataka, Ryo Sueyoshi, Manabu Okawada, Geoffrey J. Lane, Takanori Ochi, Hiroyuki Koga |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Pediatrics Prenatal diagnosis Functional Laterality Ultrasonography Prenatal 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Cystic Adenomatoid Malformation of Lung Congenital Pediatric surgery Medicine Humans Symptom onset Respiratory system Age of Onset Lung Retrospective Studies business.industry Infant Newborn Congenital pulmonary airway malformation Infant General Medicine medicine.disease Lobe medicine.anatomical_structure Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Surgery Histopathology Female business |
Zdroj: | Pediatric surgery international. 35(5) |
ISSN: | 1437-9813 |
Popis: | We investigated the relationship between the affected lobe and symptom onset in prenatally diagnosed congenital pulmonary airway malformation (CPAM). 53 CPAM patients diagnosed prenatally were reviewed retrospectively by creating 2 groups according to symptom onset. Group Sneo: (symptomatic during the neonatal period; n = 13) and group S > neo: (symptomatic after the neonatal period; n = 40) were compared for type of CPAM, affected lobes, types of symptoms/infections, treatment, duration of follow-up, and histopathology. Requirement for surgery (Sx) was then used to create three subgroups: Sneo + Sx, S > neo + Sx, and Sx−. Some cases had multiple affected lobes. In Sneo, symptoms developed in 55.6%, 50.0%, 0%, 0%, and 36.8% of right upper lobes (RUL), right middle lobes (RML), right lower lobes (RLL), left upper lobes (LUL), and left lower lobes (LLL) diagnosed with CPAM, prenatally. In S > neo, symptoms developed in 0%, 0%, 6.3%, 55.6%, and 33.3% of RUL, RML, RLL, LUL, and LLL diagnosed with CPAM, prenatally. In prenatally diagnosed CPAM, RUL and RML lesions are more likely to become symptomatic in neonates, and LUL lesions in infants. Surgery is recommended before the onset of respiratory infections after 1 year of age. |
Databáze: | OpenAIRE |
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