Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice

Autor:	Chiho Sumi‐Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazunao Kondo
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Male Neurons Alcohol Oxidoreductases Mice Norepinephrine Tyrosine 3-Monooxygenase Genetics Animals Humans Priapism Biopterin Genetics (clinical)
Zdroj:	J Inherit Metab Dis. 45:621-634
Popis:	6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for aromatic L-amino acid hydroxylases, including tyrosine hydroxylase (TH), alkylglycerol monooxygenase, and three types of nitric oxide (NO) synthases (NOS). Sepiapterin reductase (SPR) catalyzes the third step of BH4 biosynthesis. SPR gene-disrupted (Spr
Databáze:	OpenAIRE
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