The staphylococcal exopolysaccharide PIA – Biosynthesis and role in biofilm formation, colonization, and infection
| Autor: | Thuan H. Nguyen, Michael Otto, Hoai T.T. Nguyen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Colonization
Staphylococcus aureus lcsh:Biotechnology Antimicrobial peptides Biophysics Human pathogen Review medicine.disease_cause PNAG poly-N-acetylglucosamine Biochemistry Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system MSSA methicillin-sensitive Staphylococcus aureus Biosynthesis Structural Biology Staphylococcus epidermidis lcsh:TP248.13-248.65 Genetics medicine PIA polysaccharide intercellular adhesin PNAG PIA 030304 developmental biology ComputingMethodologies_COMPUTERGRAPHICS Infectivity 0303 health sciences biology Poly-N-acetylglucosamine MRSA methicillin-resistant Staphylococcus aureus Biofilm Polysaccharide intercellular adhesin biology.organism_classification CoNS coagulase-negative staphylococci Computer Science Applications chemistry 030220 oncology & carcinogenesis Device-related infection Biotechnology |
| Zdroj: | Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3324-3334 (2020) Computational and Structural Biotechnology Journal |
| ISSN: | 2001-0370 |
| Popis: | Graphical abstract Highlights • PIA is a key extracellular matrix component in staphylococci and other bacteria. • PIA is a cationic, partially deacetylated N-acetylglucosamine polymer. • PIA has a major role in bacterial biofilms and biofilm-associated infection. Exopolysaccharide is a key part of the extracellular matrix that contributes to important mechanisms of bacterial pathogenicity, most notably biofilm formation and immune evasion. In the human pathogens Staphylococcus aureus and S. epidermidis, as well as in many other staphylococcal species, the only exopolysaccharide is polysaccharide intercellular adhesin (PIA), a cationic, partially deacetylated homopolymer of N-acetylglucosamine, whose biosynthetic machinery is encoded in the ica locus. PIA production is strongly dependent on environmental conditions and controlled by many regulatory systems. PIA contributes significantly to staphylococcal biofilm formation and immune evasion mechanisms, such as resistance to antimicrobial peptides and ingestion and killing by phagocytes, and presence of the ica genes is associated with infectivity. Due to its role in pathogenesis, PIA has raised considerable interest as a potential vaccine component or target. |
| Databáze: | OpenAIRE |
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