Long-term survival after hospitalization for acute heart failure--differences in prognosis of acutely decompensated chronic and new-onset acute heart failure
| Autor: | Johan P E, Lassus, Krista, Siirilä-Waris, Markku S, Nieminen, Jukka, Tolonen, Tuukka, Tarvasmäki, Keijo, Peuhkurinen, John, Melin, Kari, Pulkki, Veli-Pekka, Harjola, O, Surakka |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty Time Factors Population Cohort Studies Interquartile range Internal medicine medicine Humans Hospital Mortality Prospective Studies education Aged Aged 80 and over Heart Failure education.field_of_study Ejection fraction business.industry Mortality rate Hazard ratio Middle Aged medicine.disease Prognosis Hospitalization Survival Rate Blood pressure Heart failure Acute Disease Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 168(1) |
| ISSN: | 1874-1754 |
| Popis: | To analyze the five-year mortality after hospitalization for acute heart failure (AHF) and compare predictors of prognosis in patients with and without a previous history of heart failure.Patients with AHF (n=620) from the prospective multicenter FINN-AKVA study were classified as acutely decompensated chronic heart failure (ADCHF) or de-novo AHF if no previous history of heart failure was present. Both all-cause mortality during five years of follow-up and prognostic factors were determined.The overall mortality was 60.3% (n=374) at five years. ADCHF was associated with significantly poorer outcome compared to de-novo AHF; five-year mortality rate 75.6% vs. 44.4% (p0.001). Initially, mortality was high (33.5% in ADCHF and 21.7% in de-novo AHF after 12 months), but in de-novo AHF the annual mortality declined markedly already after the first year. Compared to de-novo AHF, patients with ADCHF had an increased risk of death for several years after the index hospitalization. A previous history of heart failure was an independent predictor of five-year mortality (adjusted hazard ratio 1.8 (95% CI 1.4-2.2; p0.001). Older age and impaired renal function were associated with adverse long-term prognosis in both ADCHF and de-novo AHF, while higher systolic blood pressure on admission predicted better outcome.The long-term prognosis after hospitalization for AHF is poor, with a significantly different survival observed in patients with de-novo AHF compared to ADCHF. A previous history of heart failure is an independent predictor of five-year mortality. Distinction between ADCHF and de-novo AHF may improve our understanding of patients with AHF. |
| Databáze: | OpenAIRE |
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