Effect of Ciprofloxacin on the Pharmacokinetics and Pharmacodynamics of Warfarin
| Autor: | Debra S. Israel, William Rock, John T. Lettieri, Charles D. Sintek, John P. Toscano, Catherine Klein, Jennifer L. Stotka, Allen H. Heller, William R. Swaim, Ron E. Polk, Alan K. Kamada, Robert E. Pluhar |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Pharmacology Placebo Gastroenterology Anti-Infective Agents Double-Blind Method Pharmacokinetics Ciprofloxacin Internal medicine medicine Humans Drug Interactions Contraindication Aged Aged 80 and over Clotting factor Prothrombin time medicine.diagnostic_test business.industry Warfarin Anticoagulants Factor VII Middle Aged Infectious Diseases Pharmacodynamics Prothrombin Time Female Prothrombin business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 22:251-256 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | To determine if ciprofloxacin therapy alters the response to warfarin treatment, 36 adult patients attending three university-affiliated outpatient anticoagulation clinics randomly received a 12-day course of ciprofloxacin (750 mg twice daily) and a 12-day course of placebo; each course was separated by a 2-week washout period. Prothrombin times (PTs), concentrations of S-warfarin and R-warfarin (the isomers of warfarin), and concentrations of clotting factors II and VII were determined three times weekly for 9 weeks. By day 12 of ciprofloxacin therapy, concentrations of S-warfarin remained unchanged compared with those after placebo therapy, but R-warfarin concentrations increased significantly (1.15 times those after placebo therapy; P = .001); concentrations of clotting factors II and VII decreased (0.903 and 0.872 times those after placebo therapy, respectively, P < or = .020). The mean PT ratio after 12 days of ciprofloxacin therapy increased slightly (1.032 times that after placebo therapy; P = .057), but no patient had bleeding or a change in PT that required alteration in warfarin or ciprofloxacin therapy. We conclude that warfarin therapy is not a contraindication to the use of ciprofloxacin. |
| Databáze: | OpenAIRE |
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