Intravenous immunoglobulin, HLA allele typing and HLAMatchmaker facilitate successful transplantation in highly sensitized pediatric renal allograft recipients
| Autor: | Cheryl Lang, Sandra L. Nehlsen-Cannarella, Abubakr A. Imam, Rudolph P. Valentini, Tej K. Mattoo, Scott A. Gruber, Miguel S. West |
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| Rok vydání: | 2007 |
| Předmět: |
Reoperation
Urinary system Human leukocyte antigen Antibodies medicine Humans Transplantation Homologous Child Kidney transplantation Immunosuppression Therapy Transplantation Kidney biology Donor selection business.industry Histocompatibility Testing Panel reactive antibody Immunoglobulins Intravenous medicine.disease Kidney Transplantation medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology biology.protein Immunization Antibody business Immunosuppressive Agents Software |
| Zdroj: | Pediatric Transplantation. 11:77-81 |
| ISSN: | 1399-3046 1397-3142 |
| DOI: | 10.1111/j.1399-3046.2006.00617.x |
| Popis: | The use of intravenous immunoglobulin (IVIG) in sensiti- zed transplant candidates has resulted in reduced HLA antibody levels and shorter transplant wait times. In addition, the HLA- Matchmaker program has been used to identify acceptable mis- matches to permit transplantation in highly sensitized patients. We used IVIG desensitization in conjunction with high resolution HLA allele typing and HLAMatchmaker grading of donor offers to facilitate successful transplantation in two highly sensitized children who were awaiting second renal transplants. Both patients lost their initial transplant in |
| Databáze: | OpenAIRE |
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