Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
| Autor: | Yong Wei, Toni Celià-Terrassa, Xiang Hang, Sushil Kumar, John J. Grady, Julie Hwang, Hans Clevers, Jia Peng, Abrar Choudhury, Iannis Aifantis, Johan H. van Es, Ming O. Li, Yibin Kang, Briana G. Nixon, Jie Gao, Rumela Chakrabarti, Christina DeCoste |
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| Přispěvatelé: | Hubrecht Institute for Developmental Biology and Stem Cell Research |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Receptors Notch/metabolism Stromal cell Intercellular Signaling Peptides and Proteins/genetics Knockout Morphogenesis Notch signaling pathway Cell Count Biology Ligands Stromal Cells/cytology 03 medical and health sciences Gene Knockout Techniques Mice Wnt Proteins/metabolism Calcium-binding protein Receptors Stem Cells/cytology Animals Notch/metabolism Receptor Mice Knockout Multidisciplinary Stem Cell Niche/physiology Wnt signaling pathway Macrophages/cytology Mammary Glands Cell biology 030104 developmental biology Mammary Glands Animal/cytology Female Signal transduction Stem cell Animal/cytology Signal Transduction |
| Zdroj: | Science, 360(6396). American Association for the Advancement of Science (AAAS) |
| ISSN: | 0036-8075 |
| DOI: | 10.1126/science.aan4153 |
| Popis: | Cross-talk in the mammary gland Macrophages engulf damaged and dead cells to clear infection, but they also participate in tissue regeneration. Chakrabarti et al. expand the macrophage repertoire for mammary gland development (see the Perspective by Kannan and Eaves). Mammary gland stem cells secrete the Notch ligand Dll1 and activate Notch signaling, which promotes survival of adjacent macrophages. This stimulates production of Wnt ligands, which signal back to the mammary gland stem cells. This cross-talk plays an important role in coordinating mammary gland development, tissue homeostasis, and, not least, breast cancer. Science , this issue p. eaan4153 ; see also p. 1401 |
| Databáze: | OpenAIRE |
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