Arterial oxygen saturation, COPD, and cerebral small vessel disease

Autor: Albert Hofman, J van de Minkelis, de Jan Groot, Matthijs Oudkerk, Niels D. Prins, Sarah E. Vermeer, Peter J. Koudstaal, E.J. van Dijk, Monique M.B. Breteler
Přispěvatelé: Epidemiology, Neurology, Rijksuniversiteit Groningen
Jazyk: Dutch; Flemish
Rok vydání: 2004
Předmět:
Male
Myocardial Infarction
HYPOXIA
Left ventricular hypertrophy
Body Mass Index
Hemoglobins
Pulmonary Disease
Chronic Obstructive
Oximetry
Myocardial infarction
COPD
education.field_of_study
CARDIOVASCULAR HEALTH
medicine.diagnostic_test
Smoking
Brain
WHITE-MATTER LESIONS
Magnetic Resonance Imaging
Psychiatry and Mental health
Cholesterol
Hypertension
Cardiology
Female
Hypertrophy
Left Ventricular
Brain Infarction
Paper
medicine.medical_specialty
Population
ROTTERDAM SCAN
ELDERLY-PEOPLE
Internal medicine
Diabetes Mellitus
medicine
Humans
cardiovascular diseases
VASCULAR DEMENTIA
education
Vascular dementia
Aged
BLOOD-FLOW
business.industry
medicine.disease
COGNITIVE FUNCTION
Confidence interval
Hyperintensity
respiratory tract diseases
Surgery
Oxygen
Pulse oximetry
RISK-FACTORS
Neurology (clinical)
business
PULSE OXIMETRY
Zdroj: Journal of Neurology Neurosurgery and Psychiatry, 75, 733-736. BMJ Publishing Group
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 75(5), 733-736. BMJ PUBLISHING GROUP
ISSN: 1468-330X
0022-3050
DOI: 10.1136/jnnp.2003.022012
Popis: Objective: To study whether lower arterial oxygen saturation (SaO2) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts. Methods: We measured SaO2 twice with a pulse oximeter, assessed the presence of COPD, and performed MRI in 1077 non-demented people from a general population (aged 60–90 years). We rated periventricular white matter lesions (on a scale of 0–9) and approximated a total subcortical white matter lesion volume (range 0–29.5 ml). All analyses were adjusted for age and sex and additionally for hypertension, diabetes, body mass index, pack years smoked, cholesterol, haemoglobin, myocardial infarction, and left ventricular hypertrophy. Results: Lower SaO2 was independent of potential confounders associated with more severe periventricular white matter lesions (score increased by 0.12 per 1% decrease in SaO2 (95% confidence interval 0.01 to 0.23)). Participants with COPD had more severe periventricular white matter lesions than those without (adjusted mean difference in score 0.70 (95% confidence interval 0.23 to 1.16)). Lower SaO2 and COPD were not associated with subcortical white matter lesions or lacunar infarcts. Conclusion: Lower SaO2 and COPD are associated with more severe periventricular white matter lesions.
Databáze: OpenAIRE
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