Reopening of the ductus arteriosus in preterm infants; Clinical aspects and subsequent consequences

Autor: Nurdan Uraş, F Yavanoglu Atay, M Yekta Oncel, Halit Halil, Mehmet Büyüktiryaki
Rok vydání: 2018
Předmět:
Male
congenital
hereditary
and neonatal diseases and abnormalities
Pediatrics
medicine.medical_specialty
Gestational Age
Ibuprofen
Infant
Premature
Diseases
Sepsis
03 medical and health sciences
Drug treatment
0302 clinical medicine
030225 pediatrics
Ductus arteriosus
medicine
Humans
cardiovascular diseases
030212 general & internal medicine
Ductus Arteriosus
Patent
Retrospective Studies
Neonatal sepsis
Dose-Response Relationship
Drug
business.industry
Anti-Inflammatory Agents
Non-Steroidal
Hemodynamics
Infant
Newborn
Infant
Retinopathy of prematurity
Ductus Arteriosus
medicine.disease
Low birth weight
medicine.anatomical_structure
Treatment Outcome
Bronchopulmonary dysplasia
Small gestational age
embryonic structures
Pediatrics
Perinatology and Child Health
cardiovascular system
Female
medicine.symptom
business
Infant
Premature
Zdroj: Journal of neonatal-perinatal medicine. 11(3)
ISSN: 1878-4429
Popis: Objective Patent ductus arteriosus is a common problem frequently encountered in preterm infants. We aimed to study the risk factors associated with reopening of patent ductus arteriosus and their short term outcomes in preterm infants. Methods A total of 162 preterm infants born between November 2013 and December 2015 with gestaional age less than 32 weeks and treated for hemodynamically significant patent ductus arteriosus are included in our study. Results 113(69.8%) showed permanent closure and 49(30.2%) infants revealed symptoms of reopening after effective closure of patent ductus arteriosus. Low birth weight and small gestational age were more common in reopening group. Multivariete analysis showed that sepsis and multiple courses of drug treatment were independent factors affecting reopening of hemodynamically significant patent ductus arteriosus (OR: 3.01, 95% CI 1.48-6.13, p = 0.002) and (OR: 2.67, 95% CI 1.23-5.82, p = 0.013) respectively. Reopened group had a remarkable higher rate of developing necrotising nnterocolitis, bronchopulmonary dysplasia and retinopathy of prematurity than the closed group. (16.3% vs 4.4%, p = 0.01, 55.1% vs 28.3%, p = 0.001 and 55.1% vs 23.0%, p = 0.0001 respectively). Conclusion Late neonatal sepsis and the need of multiple drug courses to close patent ductus arteriosus are risk factors affecting the reopening of patent ductus arteriosus in preterm infants.
Databáze: OpenAIRE
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