An electron microscope study of cholesterol atherosclerosis in the rabbit
| Autor: | W.J.S. Still |
|---|---|
| Rok vydání: | 1963 |
| Předmět: |
Cell type
Pathology medicine.medical_specialty Arteriosclerosis Clinical Biochemistry Aortic Diseases Electrons Pathology and Forensic Medicine law.invention chemistry.chemical_compound law medicine.artery Microscopy medicine Molecular Biology Foam cell Aorta Cholesterol Research Rabbit (nuclear engineering) Atherosclerosis medicine.disease Microscopy Electron chemistry lipids (amino acids peptides and proteins) Rabbits Electron microscope |
| Zdroj: | Experimental and Molecular Pathology. 2:491-502 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/0014-4800(63)90026-1 |
| Popis: | Lesions produced in the rabbit aorta by cholesterol and cottonseed oil were studied with the electron microscope. These lesions showed two main cell types: vacuolated cells containing complex lipid inclusions (foam cells) and smaller cells containing inclusions of mainly unsaturated lipid. Foam cells and monocytoid cells were seen deposited on the endothelial surface and in some instances apparently penetrating it. Degeneration of individual endothelial cells was also observed with the occasional extrusion of underlying intimal cells. It is postulated that the foam cell is derived from the circulating blood as distinct from the other main cell type, which is derived from the smooth muscle of the aorta. |
| Databáze: | OpenAIRE |
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