T Cell Homeostatic Proliferation Promotes a Redox State That Drives Metabolic and Epigenetic Upregulation of Inflammatory Pathways in Lupus
| Autor: | Christopher D. Scharer, Scott Legunn, Ramiro Barrantes-Reynolds, Karen A. Fortner, Ralph C. Budd |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
CD4-Positive T-Lymphocytes
Physiology T-Lymphocytes Clinical Biochemistry Endogeny Biology Biochemistry Redox Article Epigenesis Genetic Mice Downregulation and upregulation immune system diseases medicine Animals Humans Lupus Erythematosus Systemic Epigenetics skin and connective tissue diseases Molecular Biology General Environmental Science Cell Proliferation Systemic lupus erythematosus Cell Biology medicine.disease Up-Regulation DNA demethylation DNA methylation Cancer research Leukocytes Mononuclear General Earth and Planetary Sciences Inflammatory pathways Oxidation-Reduction |
| Zdroj: | Antioxid Redox Signal |
| Popis: | SIGNIFICANCE: Numerous abnormalities in T cells have been described in patients with systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation, expression of endogenous retroviruses (ERVs), increased cell death, enlarged mitochondria, production of reactive oxygen species (ROS), and the appearance of unusual CD4(−)CD8(−) T cells. Our studies propose a model in which accelerated homeostatic proliferation of T cells promotes an epigenetic and metabolic program, leading to this cluster of abnormalities. RECENT ADVANCES: Growing knowledge of the innate immune disorders in SLE has included increased mitochondrial size and ROS production that induces oligomerization of the mitochondrial antiviral signaling (MAVS) protein and type I interferon production, as well as DNA demethylation, upregulation of inflammatory genes, and expression of certain ERVs in SLE peripheral blood mononuclear cells. All these events are part of the cellular program that occurs during homeostatic proliferation of T cells. Evidence from a murine model of SLE as well as in human SLE reveals that increased T cell homeostatic proliferation may be a driving factor in these processes. CRITICAL ISSUES: Despite extensive knowledge of the myriad autoantibodies in SLE and other immune abnormalities, a cogent model has been lacking to link the numerous and seemingly disparate immune aberrations. This may partly explain the general lack of new drugs specifically for SLE in over 50 years. A more coherent model of SLE would not only unify the variety of immune abnormalities is SLE but would also suggest new therapies. FUTURE DIRECTIONS: The model of augmented homeostatic proliferation leading to increased mitochondrial mass, ROS, DNA demethylation, and upregulation of inflammatory genes suggests strategic new targets for SLE, including antioxidants and certain inhibitors of metabolism. Antioxid. Redox Signal. 36, 410–422. |
| Databáze: | OpenAIRE |
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