A Single Dose Tinidazole and Doxycycline Prophylaxis in Elective Surgery of Colon and Rectum
| Autor: | Knut Nygaard, K. O. Viddal, Karl Erik Giercksky, J. A. Johnson, O. Garberg, E. Ofstad, O. Holter, S. Danielsen, Grüner Op, J. Stadaas |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Rectum Drug Administration Schedule Tinidazole Colonic Diseases chemistry.chemical_compound medicine Humans Surgical Wound Infection Prospective Studies Elective surgery Prospective cohort study Aged Doxycycline Nitroimidazole business.industry Middle Aged Antimicrobial Colorectal surgery Surgery Rectal Diseases medicine.anatomical_structure chemistry Nitroimidazoles Anesthesia Drug Therapy Combination Female business Research Article medicine.drug |
| Zdroj: | Annals of Surgery. 195:227-231 |
| ISSN: | 0003-4932 |
| Popis: | Antimicrobial prophylaxis with agents active against aerobic and anaerobic micro-organisms leads to a significant reduction of infectious complications following colorectal surgery. A single dose (1600 mg) of tinidazole (a nitroimidazole derivate) and doxycycline (400 mg) will provide serum and tissue values well above minimum inhibitory concentration (MIC) values for more than 24 hours. To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken. Six patients given a single dose of prophylaxis before operation (n = 118) developed infectious complication (5.1%). Prolongation of prophylaxis before operation for four days after operation (n = 116) did not lead to any further reduction of infectious complications. A single dose of tinidazole and doxycycline before operation is a simple and effective prophylaxis against infectious complications following elective colorectal surgery. |
| Databáze: | OpenAIRE |
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