Development of plant-based mucosal vaccines against widespread infectious diseases
| Autor: | N. I. Rekoslavskaya, Maria Manuela Rigano, Rurick K Salyaev |
|---|---|
| Přispěvatelé: | Salyaev, R. K., Rigano, MARIA MANUELA, Rekoslavskaya, N. I. |
| Rok vydání: | 2010 |
| Předmět: |
Tuberculosis
Immunology Human immunodeficiency virus (HIV) Biology medicine.disease_cause Mucosal vaccine Communicable Diseases Solanum lycopersicum Antigen Immunity Tobacco Drug Discovery medicine Humans Technology Pharmaceutical Hepatitis B Vaccines Tuberculosis Vaccines Immunity Mucosal AIDS Vaccines Pharmacology Vaccines Synthetic Vaccination food and beverages Plant based Hepatitis B Plants Genetically Modified medicine.disease Virology Immunization Molecular Medicine Biotechnology |
| Zdroj: | Expert Review of Vaccines. 9:937-946 |
| ISSN: | 1744-8395 1476-0584 |
| DOI: | 10.1586/erv.10.81 |
| Popis: | Mucosal vaccination is a perspective for the control of infectious diseases, since it is capable of inducing humoral and cell-mediated responses. In addition, the delivery of vaccines to mucosal surfaces makes immunization practice safe and acceptable, and eliminates needle-associated risks. Transgenic plants can be used as bioreactors for the production of mucosally delivered protective antigens. This technology shows great promise to simplify and decrease the cost of vaccine delivery. Herein, we review the development of mucosally administered vaccines expressed in transgenic plants. In particular, we evaluate the advantages and disadvantages of using plants for the production of mucosal vaccines against widespread infectious diseases such as HIV, hepatitis B and TB. |
| Databáze: | OpenAIRE |
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