Quality of life in idiopathic dystonia: a systematic review
| Autor: | Girach, Ayesha, Vinagre Aragon, Ana, Zis, Panagiotis |
|---|---|
| Přispěvatelé: | Zis, Panagiotis [0000-0001-8567-3092], Vinagre Aragon, Ana [0000-0002-2368-3196], Girach, Ayesha [0000-0001-8451-7127] |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
QoL Neurology Deep brain stimulation medicine.medical_treatment Blepharospasm DBS Disease Review 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation BEB Quality of life medicine otorhinolaryngologic diseases Humans 030212 general & internal medicine Cervical dystonia Dystonia business.industry medicine.disease Botulinum toxin humanities CD Dystonic Disorders Quality of Life BTX Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neurology J. Neurol. |
| ISSN: | 1432-1459 |
| Popis: | OBJECTIVE: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in idiopathic focal, segmental, multifocal and generalized dystonia. We identified 75 studies meeting our inclusion criteria. Information was extracted regarding prevalence, demographics and response to treatment where indicated. RESULTS: This review revealed QoL to be a significant yet often overlooked issue in idiopathic dystonia. Data consistently showed that dystonia has a negative effect on QoL in patients compared to healthy controls, when measured using disease-specific and generic QoL measures. The majority of studies (n = 25) involved patients with cervical dystonia, followed by benign-essential blepharospasm (n = 10). Along with the beneficial effect to the dystonia symptoms, treatment using Botulinum Toxin and Deep Brain Stimulation is also effective in improving overall QoL across the majority of subtypes. CONCLUSION: The findings demonstrate that patients' QoL should routinely be assessed and monitored, as this may affect subsequent management. Further research will allow for more robust management of factors contributing to impaired QoL, aside from the physical defects found in dystonia. 266 12 2897 2906 |
| Databáze: | OpenAIRE |
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