Cutting Edge: Lung-Resident T Cells Elicited by SARS-CoV-2 Do Not Mediate Protection against Secondary Infection
| Autor: | Lydia M. Roberts, Tara D. Wehrly, Catharine M. Bosio, Forrest Jessop |
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| Rok vydání: | 2021 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adoptive cell transfer viruses Secondary infection T cell Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Mice Transgenic T-Cell Antigen Receptor Specificity CD8-Positive T-Lymphocytes Biology Article Mice Immune system Immunity medicine Animals Humans Immunology and Allergy Lung Cells Cultured Disease Resistance SARS-CoV-2 biochemical phenomena metabolism and nutrition Adoptive Transfer Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Spike Glycoprotein Coronavirus Angiotensin-Converting Enzyme 2 CD8 |
| Zdroj: | J Immunol |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Immunity to pulmonary infection typically requires elicitation of lung-resident T cells that subsequently confer protection against secondary infection. The presence of tissue-resident T cells in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) convalescent patients is unknown. Using a sublethal mouse model of coronavirus disease 2019, we determined if SARS-CoV-2 infection potentiated Ag-specific pulmonary resident CD4+ and CD8+ T cell responses and if these cells mediated protection against secondary infection. S protein–specific T cells were present in resident and circulating populations. However, M and N protein–specific T cells were detected only in the resident T cell pool. Using an adoptive transfer strategy, we found that T cells from SARS-CoV-2 immune animals did not protect naive mice. These data indicate that resident T cells are elicited by SARS-CoV-2 infection but are not sufficient for protective immunity. |
| Databáze: | OpenAIRE |
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