Polyoxometalate Modified by Zeolite Imidazole Framework for the pH-Responsive Electrodynamic/Chemodynamic Therapy
| Autor: | Yan Song, Yuan Sun, Minglu Tang, Zhengya Yue, Jiatong Ni, Junge Zhao, Wenxin Wang, Tiedong Sun, Lianxu Shi, Lei Wang |
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| Rok vydání: | 2022 |
| Předmět: |
Anions
Mice Inbred BALB C Surface Properties Imidazoles Antineoplastic Agents Biocompatible Materials Neoplasms Experimental Hydrogen-Ion Concentration Combined Modality Therapy Polyelectrolytes Mice Materials Testing Tumor Microenvironment Zeolites Animals Humans Female General Materials Science Drug Screening Assays Antitumor Particle Size Reactive Oxygen Species Cell Proliferation HeLa Cells |
| Zdroj: | ACS Applied Materials & Interfaces. 14:4914-4920 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Electrodynamic therapy (EDT) and chemodynamic therapy (CDT) have the potential for future tumor treatment; however, their underlying applications are greatly hindered owing to their inherent drawbacks. The combination of EDT and CDT has been considered to be an effective way to maximize the superiorities of these two ROS-based methodologies. However, the development of novel nanomaterials with "one-for-all" functions still remains a big challenge. In this work, the polyoxometalate nanoparticles (NPs) were decorated using the zeolite imidazole framework (POM@ZIF-8) in order to integrate the EDT with CDT. The resulting POM@ZIF-8 NPs can effectively induce the generation of reactive oxygen species (ROS) |
| Databáze: | OpenAIRE |
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