Stimulation Effect of Galanin-Like Peptide (GALP) on Luteinizing Hormone-Releasing Hormone-Mediated Luteinizing Hormone (LH) Secretion in Male Rats
| Autor: | Osamu Nishimura, Yasuko Horikoshi, Takashi Itoh, Jiro Noguchi, Hirokazu Matsumoto, Chieko Kitada, Satoshi Kumano, Masahiko Fujino, Yoshihiro Takatsu, Haruo Onda, Tetsuya Ohtaki |
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| Rok vydání: | 2001 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Galanin Nerve Tissue Proteins Gonadotropin-releasing hormone Gonadotropin-Releasing Hormone chemistry.chemical_compound Hormone Antagonists Endocrinology Internal medicine Galanin-like peptide medicine Animals Rats Wistar Injections Intraventricular biology GalP digestive oral and skin physiology Luteinizing Hormone Immunohistochemistry Rats Gonadotropin secretion nervous system chemistry Hypothalamus Pituitary Gland biology.protein Luteinizing hormone Proto-Oncogene Proteins c-fos Receptors LHRH hormones hormone substitutes and hormone antagonists Gonadotropin-releasing hormone receptor Galanin-Like Peptide |
| Zdroj: | Endocrinology. 142:3693-3696 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.142.8.8432 |
| Popis: | Galanin-like peptide (GALP) is a recently isolated hypothalamic peptide which has sequence homology to galanin and binds to galanin receptors with high affinity. It has been shown that GALP neurons are localized in the arcuate nucleus and that GALP-immunoreactive fibers are in close apposition with LHRH neurons in the medial preoptic area (MPA). In the present study, we found that intracerebroventricular (icv) administration of GALP increased the plasma LH level but did not change the levels of other hormones. Concomitantly, accumulation of c-Fos protein was dramatically increased in the nuclei of LHRH-positive cells in the MPA by icv GALP administration. Furthermore, the GALP-induced plasma LH response was completely abolished by pretreatment with Cetrorelix, a LHRH receptor antagonist. On the other hand, GALP did not affect the release of LH, FSH, TSH, ACTH, GH or PRL directly from dispersed rat pituitary cells in vitro. These results strongly suggest a role for GALP in the control of gonadotropin secretion through a hypothalamic mechanism involving the release of LHRH. |
| Databáze: | OpenAIRE |
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