Maternal and neonatal outcomes in 80 patients diagnosed with non-Hodgkin lymphoma during pregnancy: results from the International Network of Cancer, Infertility and Pregnancy

Autor: Daan Dierickx, Charlotte Maggen, Petronella B. Ottevanger, Andie O'Laughlin, Alvaro Cabrera-Garcia, Bianca Masturzo, Elyce Cardonick, Johannes J. Duvekot, Mina Mhallem Gziri, Evgeniya Polushkina, Roman G. Shmakov, Frédéric Amant, Irit Avivi, F J Sherida H Woei-A-Jin, Kristel Van Calsteren
Přispěvatelé: Obstetrics, UCL - (SLuc) Service d'obstétrique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, Obstetrics and Gynaecology, ARD - Amsterdam Reproduction and Development
Rok vydání: 2021
Předmět:
Cyclophosphamide/administration & dosage
Congenital Abnormalities/epidemiology
Antibodies
Monoclonal
Murine-Derived
0302 clinical medicine
Antineoplastic Agents
Immunological
Lymphoma
Large B-Cell
Diffuse/complications
Prednisone
Pregnancy
immune system diseases
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Vincristine/administration & dosage
Antineoplastic Agents
Immunological/therapeutic use
Fetal Growth Retardation/chemically induced
Fetal Growth Retardation
Obstetrics
Standard treatment
Stillbirth/epidemiology
non-Hodgkin lymphoma
Incidence
Lymphoma
Non-Hodgkin
Pregnancy Outcome
Hematology
Antineoplastic Combined Chemotherapy Protocols/administration & dosage
Stillbirth
Progression-Free Survival
3. Good health
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
R-CHOP
Vincristine
030220 oncology & carcinogenesis
Antibodies
Monoclonal
Murine-Derived/therapeutic use
Premature Birth
Female
pregnancy
Lymphoma
Large B-Cell
Diffuse
Rituximab
Cohort study
medicine.drug
Prednisolone/administration & dosage
Adult
medicine.medical_specialty
Lymphoma
Non-Hodgkin/diagnosis
Adolescent
Prednisolone
diffuse large B-cell lymphoma
Gestational Age
Pregnancy Outcome/epidemiology
Hodgkin Lymphoma During Pregnancy
Congenital Abnormalities
03 medical and health sciences
Rituximab/therapeutic use
medicine
Pregnancy Complications/chemically induced
Humans
Cyclophosphamide
Retrospective Studies
business.industry
Doxorubicin/administration & dosage
Infant
Newborn
medicine.disease
maternal outcome
Pregnancy Complications
Infertility/chemically induced
Doxorubicin
Infertility
Premature Birth/chemically induced
Small for gestational age
business
Diffuse large B-cell lymphoma
030215 immunology
Zdroj: British Journal of Haematology, 193, 52-62
British Journal of Haematology, 193, 1, pp. 52-62
British journal of haematology, Vol. 193, no. 1, p. 52-62 (2021)
British Journal of Haematology
British journal of haematology, 193(1), 52-62. Wiley-Blackwell
ISSN: 0007-1048
Popis: This cohort study of the International Network on Cancer, Infertility and Pregnancy (INCIP) reports the maternal and neonatal outcomes of 80 pregnant patients diagnosed with non-Hodgkin lymphoma (NHL) between 1986 and 2019, focussing on 57 (71%) patients with diffuse large B-cell lymphoma (DLBCL). Of all 80 patients, 54 (68%) pregnant patients received chemotherapy; mostly (89%) CHOP-like (cyclophosphamide, doxorubicin, vincristine, and prednisone) regimens. Four early pregnancies were terminated. Among 76 ongoing pregnancies, there was one stillbirth (1·3%). Overall, there was a high incidence of small for gestational age neonates (39%), preterm delivery (52%), obstetric (41%) and neonatal complications (12·5%), and this could not exclusively be explained by the receipt of antenatal chemotherapy. Half of preterm deliveries (46%) were planned in order to tailor oncological treatment. The 3-year progression-free and overall survival for patients with DLBCL treated with rituximab-CHOP was 83·4% and 95·7% for limited stage (n = 29) and 60·6% and 73·3% for advanced stage (n = 15). Of 36 pregnant patients who received rituximab, five (13%) cases with neonatal complications and three (8%) with maternal infections were reported. In conclusion, standard treatment for DLBCL can be offered to pregnant patients in obstetric centres that cater for high-risk patients. ispartof: BRITISH JOURNAL OF HAEMATOLOGY vol:193 issue:1 pages:52-62 ispartof: location:England status: published
Databáze: OpenAIRE
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