The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies
Autor: | Caroline Cheng, Dana A M Mustafa, Johan M Kros, Changbin Zhu |
---|---|
Přispěvatelé: | Pathology, Cardiology |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cancer Research Angiogenesis Population Cell Reviews Inflammation Metastasis Neovascularization 03 medical and health sciences 0302 clinical medicine stomatognathic system Glioma Tumor Microenvironment medicine Animals Humans skin and connective tissue diseases education education.field_of_study Neovascularization Pathologic business.industry Macrophages Cancer medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Immunotherapy Neurology (clinical) medicine.symptom business hormones hormone substitutes and hormone antagonists |
Zdroj: | Neuro-Oncology, 19(11), 1435-1446. Oxford University Press |
ISSN: | 1523-5866 1522-8517 |
Popis: | "Tumor-associated macrophages" (TAMs) form a significant cell population in malignant tumors and contribute to tumor growth, metastasis, and neovascularization. Gliomas are characterized by extensive neo-angiogenesis, and knowledge of the role of TAMs in neovascularization is important for future anti-angiogenic therapies. The phenotypes and functions of TAMs are heterogeneous and more complex than a classification into M1 and M2 inflammation response types would suggest. In this review, we provide an update on the current knowledge of the ontogeny of TAMs, focusing on diffuse gliomas. The role of TAMs in the regulation of the different processes in tumor angiogenesis is highlighted and the most recently discovered mechanisms by which TAMs mediate resistance against current antivascular therapies are mentioned. Novel compounds tested in clinical trials are discussed and brought in relation to different TAM-related angiogenesis pathways. In addition, potential therapeutic targets used to intervene in TAM-regulated tumor angiogenesis are summarized. |
Databáze: | OpenAIRE |
Externí odkaz: |