Effect of 7,12-Dimethylbenz[ ] anthracene and Splenectomy on Virus Titer and Blood Picture in Friend Virus Leukemia
| Autor: | Gerd T. Schloss, Winifred K. Kiehn, Stephen C. Elliott, Christopher A. Reilly |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty medicine.medical_treatment Splenectomy DMBA Biology General Biochemistry Genetics and Molecular Biology Virus Mice chemistry.chemical_compound hemic and lymphatic diseases Benz(a)Anthracenes polycyclic compounds medicine Animals Erythropoiesis Neoplastic transformation skin and connective tissue diseases neoplasms Leukemia Experimental 7 12-Dimethylbenz[a]anthracene Friend virus Anemia Organ Size medicine.disease biology.organism_classification Blood Cell Count Friend murine leukemia virus Leukemia Cell Transformation Neoplastic medicine.anatomical_structure Liver chemistry Bone marrow Spleen |
| Zdroj: | Experimental Biology and Medicine. 133:529-535 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-133-34512 |
| Popis: | SummaryIn Friend virus leukemia, 7,12-dimethylbenz[a] anthracene (DMBA) delays the neoplastic transformation of the reticulum cells in the spleen, as shown by histologic examination, and decrease in virus titer, and suppresses their maturation to erythroblastic cells as shown by histologic examination and absence of erythroblasts in the peripheral blood. DMBA also lowers the elevated white blood cell count. Splenectomy alone prolongs the survival time in Friend virus leukemia, but it produces a rapidly fatal profound anemia when combined with DMBA, probably because of damage to the bone marrow. |
| Databáze: | OpenAIRE |
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