Stress macht Zellen resistent gegen Folsäure-basierte Chemotherapeutika
| Autor: | Robert Ahrends, Jan Medenbach |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Regulation of gene expression
0303 health sciences 030306 microbiology Pharmacology toxicology Cancer therapy Biology Human genetics Cell biology 03 medical and health sciences Regulon Cellular stress response biological sciences Unfolded protein response 570 Biowissenschaften Biologie ddc:570 Molecular Biology 030304 developmental biology Biotechnology |
| Zdroj: | BIOspektrum. 26:609-611 |
| ISSN: | 1868-6249 0947-0867 |
| Popis: | The unfolded protein response (UPR), a cellular stress response pathway, is broadly implicated in disease and resistance to therapy. The molecular mechanisms that drive stress-mediated chemoresistance are, however, only poorly understood. We have employed a multiomics approach to determine UPR-induced gene regulation, revealing the UPR regulon. We further observe metabolic rewiring upon stress and resistance to Methotrexate, a widely-employed therapeutic reagent. The precise molecular characterization of the pathway driving resistance might lead to novel concepts in cancer therapy. |
| Databáze: | OpenAIRE |
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